ANTIBACTERIAL, ANTI-ALPHA GLUCOSIDASE AND ANTIOXIDANT PROPERTIES OF DILLENIA PENTAGYNA ROXB. (DILLENIACEAE)

Objective: The persent investigation is carried out to assess in vitro antimicrobial, antioxidant and anti-alphaglucosidase activity of the crude and fraction extracts of both leaf and fruits of the plant Dillenia pentagyna Roxb. (Dilleniaceae).Methods: Extracts prepared from leaf and fruits by drying and fractionation process. Antibacterial activity assessed by disc diffusion and liquid culture method. Antioxidant activity was assayed by superoxide radical scavenging capability and by DPPH scavenging capability. By using the enzyme α-glucosidase and substrate p-nitrophenyl glucopyranoside (pNPG), the inhibitory activity of the extracts was assayed.Results: Crude extracts of fruits from both butanol fraction and chloroform fraction showed promising antibacterial activity in disc diffusion method through measuring inhibition zone. Both butanol and chloroform fraction showed a significant superoxide radical scavenging activity and using DPPH (1,1-diphenyl-2-picryl hydrazyl), butanol fraction extract of fruit showed a significant scavenging property. α-glucosidase (E.C No. 3.2.1.20) enzyme activity is inhibited significantly by the leaf extract of the plant.Conclusion: The results suggest that the crude plant extract contain some compounds which have antimicrobial activity, more potent antioxidant activity as well as α-glucosidase inhibitory activity.Keywords: Dillenia pentagyna, antimicrobial, antioxidant, antidiabetic, superoxide, α-glucosidase, DPPH