COGNITIVE STATUS OF PATIENTS WITH MULTIPLE SCLEROSIS BEFORE RECEIVING OCRELIZUMAB THERAPY

Ciljevi: Cilj ovog istraživanja bio je utvrditi kognitivni status bolesnika sa dijagnozom multiple skleroze kojima se planira primjena terapije okrelizumabom. Ispitanici i postupci: Ovo je istraživanje obuhvatilo šesnaest bolesnika Klinike za neurologiju Kliničkog bolničkog centra Split sa dijagnozom multiple skleroze prije uvođenja terapije okrelizumabom. U razdoblju od 1. lipnja do 30. lipnja 2021. godine bolesnicima je učinjeno neuropsihologijsko testiranje primjenom testne baterije koja se sastoji od devet testova, a ispituje više kognitivnih domena. Kognitivni testovi koji su korišteni su Ravenove progresivne matrice, Digit span test, Corsi test, AVLT, TMT A, TMT B, SDMT, Stroop test i MFPT. Rezultati: Utvrđene su statistički značajne varijabilnosti intertestnih vrijednosti u bolesnika sa multiplom sklerozom u Ravenovim progresivnim matricama (P=0,003), TMT A testu (P=0,001), Corsi testu (P=0,000), Digit Span testu (P=0,009) te broju pogrešnih odgovora (P=0,000) i ukupnom vremenu rješavanja (P=0,017) Stroop testa. Rezultati primjenjenih testova u bolesnika s multiplom sklerozom ne razlikuju se značajno od rezultata kontrolne skupine. Zaključci: Istraživanje je pokazalo da bolesnici s multiplom sklerozom imaju oštećenje vizuo-prostorne pretrage, izvršne brzine, mentalne fleksibilnosti i pažnje, dok su im logičko-analitičke sposobnosti i radna memorija pošteđene.Objectives: The aim of this study was to determine the cognitive status of patients with a diagnosis of multiple sclerosis who are scheduled to receive ocrelizumab therapy. Participants and interventions: This study included sixteen patients of the Clinic of Neurology of the Clinical Hospital Center Split with a diagnosis of multiple sclerosis before receiving ocrelizumab therapy. In the period from June 1 to June 30, 2021, patients underwent neuropsychological testing using a test battery consisting of nine tests and examining multiple cognitive domains. The cognitive tests used were Raven’s progressive matrices, Digit span, Corsi, AVLT, TMT A, TMT B, SDMT, Stroop, and MFPT. Results: Statistically significant variability of intertest values was found in patients with multiple sclerosis in Raven's progressive matrices (P=0.003), TMT A test (P=0.001), Corsi test (P=0.000), Digit Span test (P=0.009) and the number of wrong answers (P=0.000) and total resolution time (P=0.017) of the Stroop test. The results of the applied tests in patients with multiple sclerosis do not differ significantly from the results of the control group. Conclusions: Research has shown that patients with multiple sclerosis have impaired visuo-spatial search, information processing speed, mental flexibility and attention while their logical-analytical abilities and working memory are spared