TREATMENT OF METASTATIC HER 2 POSITIVE BREAST CANCER AT THE CLINIC FOR ONCOLOGY AND RADIOTHERAPY UNIVERSITY HOSPITAL OF SPLIT : RETROSPECTIVE ANALYSIS

Ciljevi: Primarni cilj je prikazati preživljenje bez progresije bolesti u prvoj liniji liječenja. Sekundarni ciljevi su: preživljenje bez progresije bolesti u drugoj liniji liječenja, postprogresijsko preživljenje te ukupno preživljenje u bolesnika s metastatskim HER 2 pozitivnim rakom dojke liječenih u Klinici za onkologiju i radioterapiju KBC-a Split u razdoblju od 2016. do 2020. godine, te dobivene rezultate usporediti s podatcima iz dostupne svjetske literature. Ispitanici i postupci: Retrospektivnom analizom iz baza podataka prikupljeni su podaci o 35 bolesnika kojima je u razdoblju od početka 2016. do kraja 2020. godine dijagnosticiran metastatski HER 2 pozitivni rak dojke, bilo kao inicijalno metastatska bolest ili nakon ranijeg liječenja raka dojke. U bazu podataka uvrštene su demografske karakteristike bolesnika te patohistološke i kliničke karakteristike tumora. Baza podataka zaključena je 15. svibnja 2021. Rezultati: Nije pronađena značajna razlika između učestalosti pojavnosti de novo metastatske bolesti i metastatske bolesti nakon ranijeg liječenja raka dojke. Najčešći imunofenotip je HER 2 luminalni tip. Bolesnice najčešće imaju samo jedno sijelo presadnica. Značajno češće bolesnice imaju parenhimne presadnice. Medijan preživljenja bez progresije bolesti u prvoj liniji iznosi 21,5 mjeseci. Medijan preživljenja bez progresije bolesti u drugoj liniji iznosi 11,2 mjeseca. Medijan postprogesijskog preživljenja iznosi 13 mjeseci. Medijan ukupnog preživljenja nije dosegnut. Zaključak: Ishodi liječenja bolesnika s metastatskim HER 2 pozitivnim rakom dojke liječenih u Klinici za onkologiju i radioterapiju KBC-a Split usporedivi su s rezultatima registracijskih kliničkih studija.Objectives: The primary goal is to show progression-free survival in the first line of treatment. Secondary goals are: progression-free survival in the second line of treatment, post-progressive survival and overall survival in patients with metastatic HER 2 positive breast cancer treated at the Clinic for Oncology and Radiotherapy University Hospital of Split in the period from 2016 to 2020, and obtained compare the results with data from the available world literature. Subjects and methods: A retrospective analysis was done from the database collected data on 35 patients who were diagnosed with metastatic HER 2 positive breast cancer in the period from the beginning of 2016 to the end of 2020, either as an initial metastatic disease or after previous treatment for breast cancer. The database includes demographic characteristics of patients and pathohistological and clinical characteristics of tumors. The database was closed on May 15, 2021. Results: No significant difference was found between the incidence of new metastatic diseases and metastatic diseases after previous breast cancer treatment. The most common immunophenotype is the HER 2 luminal type. Patients usually have only one site of metastasis. Significantly more often patients have parenchymal metastasis. The median progression-free survival in the first line is 21.5 months. The median progression-free survival in the second line is 11.2 months. The median postprogestion survival is 13 months. The median overall survival was not reached. Conclusion: The treatment outcomes of patients with metastatic HER 2 positive breast cancer treated at the Clinic for Oncology and Radiotherapy, University Hospital of Split are comparable to the results of registration clinical studies