Asymmetric Nitrene Transfer Reactions with Azides via Co(II)-Based Metalloradical Catalysis (MRC)

Asymmetric nitrene transfer reactions via metalloradical catalysis (MRC) with azides has attracted research interest because of its fundamental and practical importance. The resulting nitrogen-containing units are recurrent motifs in biologically important molecules and can serve as versatile precursors in organic synthesis. The [Co(D2-Por*)] have emerged as a new class of catalysts for asymmetric aziridination and C-H amination. These metalloradical catalysts have been shown to be highly effective for the asymmetric intermolecular aziridination of a broad scope of substrates with different classes of azides with excellent to good enantioselectivity. The intramolecular C-H amination utilizing various azides can allow for the construction of diverse nitrogen containing heterocyclic compounds