RecQ-like proteins are a family of DNA helicases that are evolutionary conserved from prokaryotes to eukaryotes. A large amount of experimental evidence suggests these proteins have a major role in the maintenance of genome stability. In humans five RecQ like helicase have been identified (RecQL1, BLM, WRN, RecQL4, and RecQL5), three of which are associated with rare genetic disorders with sever chromosomal and developmental abnormalities, and an elevated predisposition to cancer. Among the disease associated RecQ-like helicases, BLM and WRN have been subject to extensive research, while our collective knowledge about the function of RecQL4 is still very limited. Similarly, little is known about the role of RecQL1 and RecQL5 in maintenance ...
The RecQ helicases are involved in several aspects of DNA metabolism. Five members of the RecQ famil...
Helicases are a highly conserved family of motor proteins responsible for interacting with and unwin...
Understanding the molecular and cellular functions of RecQ helicases has attracted considerable inte...
Double-strand breaks and stalled forks arise when the replication machinery encounters damage from e...
The RecQ family of DNA helicases is highly conserved in evolution from bacteria to mammals. There ar...
The human genome encodes five RecQ helicases (RECQL1, BLM, WRN, RECQL4, and RECQL5) that participate...
AbstractThe RecQ helicases are a highly conserved family of DNA-unwinding enzymes that play key role...
Bacteria and yeast possess one RecQ helicase homolog whereas humans contain five RecQ helicases, all...
The RecQ helicases are a highly conserved family of DNA-unwinding enzymes that play key roles in pro...
Of the five human RecQ family helicases, RecQ4, BLM, andWRN suppress distinct genome instability-lin...
The RecQ family of DNA helicases is highly conserved in evolution from bacteria to humans. Of the fi...
The RecQ family of helicases has been termed the “Caretakers of the Genome,” and rightfully so. Thes...
Members of the RecQ helicase superfamily have been implicated in DNA repair, recombination and repli...
The five human RecQ helicases participate in multiple processes required to maintain genome integrit...
The Escherichia coli gene recQ was identified as a RecF recombination pathway gene(1). The gene SGS1...
The RecQ helicases are involved in several aspects of DNA metabolism. Five members of the RecQ famil...
Helicases are a highly conserved family of motor proteins responsible for interacting with and unwin...
Understanding the molecular and cellular functions of RecQ helicases has attracted considerable inte...
Double-strand breaks and stalled forks arise when the replication machinery encounters damage from e...
The RecQ family of DNA helicases is highly conserved in evolution from bacteria to mammals. There ar...
The human genome encodes five RecQ helicases (RECQL1, BLM, WRN, RECQL4, and RECQL5) that participate...
AbstractThe RecQ helicases are a highly conserved family of DNA-unwinding enzymes that play key role...
Bacteria and yeast possess one RecQ helicase homolog whereas humans contain five RecQ helicases, all...
The RecQ helicases are a highly conserved family of DNA-unwinding enzymes that play key roles in pro...
Of the five human RecQ family helicases, RecQ4, BLM, andWRN suppress distinct genome instability-lin...
The RecQ family of DNA helicases is highly conserved in evolution from bacteria to humans. Of the fi...
The RecQ family of helicases has been termed the “Caretakers of the Genome,” and rightfully so. Thes...
Members of the RecQ helicase superfamily have been implicated in DNA repair, recombination and repli...
The five human RecQ helicases participate in multiple processes required to maintain genome integrit...
The Escherichia coli gene recQ was identified as a RecF recombination pathway gene(1). The gene SGS1...
The RecQ helicases are involved in several aspects of DNA metabolism. Five members of the RecQ famil...
Helicases are a highly conserved family of motor proteins responsible for interacting with and unwin...
Understanding the molecular and cellular functions of RecQ helicases has attracted considerable inte...