Our study proposal consists of the deductible relational epistemological reflection between discursive semiotics and the Theory of Signatures exposed by Agamben (Signatura rerum: on the method, 2019), more precisely the possible relations of convergence between signature and the construction of meaning signs and in the speech that is revealed by language. The marking process, therefore, involves the inscription of values that are in line with Greimas' epistemology. In the analysis of isotopy, using Greimas' definitional analysis, the signature appears in the lexicographic definition, as a catalyst lexeme; in the discursive definition, it is shown in the reiteration of semes that corroborate the permanence of the same meaning; and, finally...