Histomorphological Study of Skin Epithelial Tumours with Immunohistochemical Evaluation of p53 Expression in Malignant Tumours
- Sulata M Kamath
- Raksha Nayak
- Vijaya V Mysorekar
DOIAbstract
Introduction: Skin is the largest organ in the body. A variety of hyperplastic growths, benign and malignant tumours are encountered in clinical practice. Although skin tumours constitute <1% in India, the prevalence has been progressively increasing over the last few decades. However, limited studies have been conducted in Indian subcontinent to study skin tumours. Reportedly, pathogenesis of skin tumours in Indians is notably distinct than that observed in white-skinned people. This highlights the high demand for studying skin tumours on a larger scale in Indian subcontinent. Moreover, genetic mutations in tumours are crucial aspects of which p53 gene mutations are predominantly involved in the development of 50% of all tumours...
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