The serum response factor (SRF) is a transcription factor involved in the regulation of cell proliferation and migration. At cytoskeletal genes, SRF acts cooperatively with the actin-regulated myocardin-related transcription factors MRTF-A and MRTF-B. In addition to regulating MRTFs’ subcellular localization, G-actin also controls their nuclear activities. Previous work showed that nuclear accumulation of MRTF-A in the absence of an activating signal is sufficient for its association with genomic loci but not for target gene activation, demonstrating a repressive effect of nuclear actin on MRTF activity. However, the exact mechanism is unclear. The data presented below demonstrates that G-actin interferes with ternary complex formation betw...
The research described in this thesis was focused on the study of signalling pathways that lead to a...
Abstract Background MRTF-A (myocardin-related transcription factor A) is a coactivator for SRF-media...
The roles of myocardin-related transcription factor A (MRTF-A) and MRTF-B in vascular endothelial ce...
Serum response factor (SRF) controls gene activation in response to changes in actin dynamics and mi...
SummaryThe serum response factor (SRF) binds to coactivators, such as myocardin-related transcriptio...
Transcription factor SRF (Serum Response Factor) and its coactivators MRTFs (Myocardin-Related Tran...
The myocardin-related transcription factors (MRTF-A and MRTF-B) regulate cytoskeletal genes through ...
Actin has important functions in both cytoplasm and nucleus of the cell, with active nuclear transpo...
Myocardin-related transcription factor A (MRTF-A), a coactivator of serum response factor (SRF), reg...
AbstractRho GTPases regulate the transcription factor SRF via their ability to induce actin polymeri...
AbstractThe serum response element (SRE) contributes to transcriptional repression of the c-fos prot...
Transcription is a very complex multi-step process presenting different levels of regulation. A larg...
In mammalian cells, actin and myosin have emerged as regulators of nuclear structure and function, i...
International audienceMyocardin-related transcription factors (MRTFs) play a central role in the reg...
MRTF-A (myocardin-related transcription factor A) is a coactivator for SRF-mediated gene expression....
The research described in this thesis was focused on the study of signalling pathways that lead to a...
Abstract Background MRTF-A (myocardin-related transcription factor A) is a coactivator for SRF-media...
The roles of myocardin-related transcription factor A (MRTF-A) and MRTF-B in vascular endothelial ce...
Serum response factor (SRF) controls gene activation in response to changes in actin dynamics and mi...
SummaryThe serum response factor (SRF) binds to coactivators, such as myocardin-related transcriptio...
Transcription factor SRF (Serum Response Factor) and its coactivators MRTFs (Myocardin-Related Tran...
The myocardin-related transcription factors (MRTF-A and MRTF-B) regulate cytoskeletal genes through ...
Actin has important functions in both cytoplasm and nucleus of the cell, with active nuclear transpo...
Myocardin-related transcription factor A (MRTF-A), a coactivator of serum response factor (SRF), reg...
AbstractRho GTPases regulate the transcription factor SRF via their ability to induce actin polymeri...
AbstractThe serum response element (SRE) contributes to transcriptional repression of the c-fos prot...
Transcription is a very complex multi-step process presenting different levels of regulation. A larg...
In mammalian cells, actin and myosin have emerged as regulators of nuclear structure and function, i...
International audienceMyocardin-related transcription factors (MRTFs) play a central role in the reg...
MRTF-A (myocardin-related transcription factor A) is a coactivator for SRF-mediated gene expression....
The research described in this thesis was focused on the study of signalling pathways that lead to a...
Abstract Background MRTF-A (myocardin-related transcription factor A) is a coactivator for SRF-media...
The roles of myocardin-related transcription factor A (MRTF-A) and MRTF-B in vascular endothelial ce...