Arylamine N-acetyltransferases, NAT1 and NAT2, catalyze the detoxification and/or activation of drugs and aromatic amine carcinogens. Single nucleotide polymorphisms or SNPs result in different human NAT2 genotypes thus dividing the population into rapid, intermediate, and slow acetylators. We hypothesize allelic variants of NAT2 genotype will decrease levels of N-acetylation, cytotoxicity, oxidative stress, DNA adduct formation, and mutagenesis compared to the reference allele NAT2*4. Cryopreserved human hepatocytes expressing different NAT2 genotypes and NER-deficient Chinese hamster ovary (CHO) cells transfected with human CYP1A2 and human NAT2*4, NAT2*5B or NAT2*7B have been used to investigate N-acetylation of different xenobiotics. In...
Many carcinogenic chemicals may require activation and inactivation by enzymes. Genetic polymorphism...
Arylamine N-acetyltransferase (NAT) is a phase II metabolizing enzyme, which belongs to the transfer...
The human N-acetylation polymorphism is a genetic trait phenotypically reflected by differences in N...
Arylamine N-acetyltransferases, NAT1 and NAT2, catalyze the detoxification and/or activation of carc...
The human N-acetylation polymorphism is a heritable variation in the ability of individuals to metab...
N-Acetyltransferase (NAT) N-acetylates various arylamine drugs (e.g., p-aminosalicylate, p-aminobenz...
Arylamine N-acetyltransferases (NATs) catalyse the N-acetylation of arylamines, arylhydroxylamines a...
The human N-acetyltransferase genes NAT1 and NAT2 encode two phase-II enzymes that metabolize variou...
Arylamine N-acetyltransferases (NATs) catalyse the N-acetylation of arylamines, arylhydroxylamines a...
The human N-acetyltransferase genes NAT1 and NAT2 encode two phase-II enzymes that metabolize variou...
The human N-acetyltransferase genes NAT1 and NAT2 encode two phase-II enzymes that metabolize variou...
The human polymorphism in the hepatic enzyme N-acetyltransferase (NAT) affects the rate at which ind...
Human N-acetyltransferase 2 (NAT2) is polymorphic and may associate with cancer risk by modifying su...
An inbred hamster model for the human acetyIation polymorphism was used to investigate the biochemic...
Human arylamine N-acetyltransferase 2 (NAT2) mediates the bio-transformation of arylamine drugs and ...
Many carcinogenic chemicals may require activation and inactivation by enzymes. Genetic polymorphism...
Arylamine N-acetyltransferase (NAT) is a phase II metabolizing enzyme, which belongs to the transfer...
The human N-acetylation polymorphism is a genetic trait phenotypically reflected by differences in N...
Arylamine N-acetyltransferases, NAT1 and NAT2, catalyze the detoxification and/or activation of carc...
The human N-acetylation polymorphism is a heritable variation in the ability of individuals to metab...
N-Acetyltransferase (NAT) N-acetylates various arylamine drugs (e.g., p-aminosalicylate, p-aminobenz...
Arylamine N-acetyltransferases (NATs) catalyse the N-acetylation of arylamines, arylhydroxylamines a...
The human N-acetyltransferase genes NAT1 and NAT2 encode two phase-II enzymes that metabolize variou...
Arylamine N-acetyltransferases (NATs) catalyse the N-acetylation of arylamines, arylhydroxylamines a...
The human N-acetyltransferase genes NAT1 and NAT2 encode two phase-II enzymes that metabolize variou...
The human N-acetyltransferase genes NAT1 and NAT2 encode two phase-II enzymes that metabolize variou...
The human polymorphism in the hepatic enzyme N-acetyltransferase (NAT) affects the rate at which ind...
Human N-acetyltransferase 2 (NAT2) is polymorphic and may associate with cancer risk by modifying su...
An inbred hamster model for the human acetyIation polymorphism was used to investigate the biochemic...
Human arylamine N-acetyltransferase 2 (NAT2) mediates the bio-transformation of arylamine drugs and ...
Many carcinogenic chemicals may require activation and inactivation by enzymes. Genetic polymorphism...
Arylamine N-acetyltransferase (NAT) is a phase II metabolizing enzyme, which belongs to the transfer...
The human N-acetylation polymorphism is a genetic trait phenotypically reflected by differences in N...