Human Orthologs of the Ribosome-Associated Complex (RAC) can Functionally Replace the Yeast RAC in S. cerevisiae

Proteins are very important for many different functions in our bodies. However, they are prone to misfold, which could make them acquire new toxic functions. In order to prevent these incidents, a special type of proteins called chaperones assist in the proper folding of different proteins. We investigated a special type of chaperones that anchor at the site of protein synthesis, the ribosome, to assist with the proper folding of proteins in yeast. The purpose of this study is to understand if the human version of these chaperones could function in S. cerevisiae