Cell–cell interactions (CCIs) and cell–cell communication (CCC) are critical for maintaining complex biological systems. The availability of single-cell RNA sequencing (scRNA-seq) data opens new avenues for deciphering CCIs and CCCs through identifying ligand-receptor (LR) gene interactions between cells. However, most methods were developed to examine the LR interactions of individual pairs of genes. Here, we propose a novel approach named LR hunting which first uses random forests (RFs)-based data imputation technique to link the data between different cell types. To guarantee the robustness of the data imputation procedure, we repeat the computation procedures multiple times to generate aggregated imputed minimal depth index (IMDI). Next...
Abstract Background Cellular communication is an essential feature of multicellular organisms. Bindi...
Innate lymphoid cells (ILCs) consist of natural killer (NK) cells and non-cytotoxic ILCs that are br...
International audienceNetworks are powerful tools to represent and investigate biological systems. T...
Cell–cell interactions (CCIs) and cell–cell communication (CCC) are critical for maintaining complex...
Cell–cell interactions (CCIs) and cell–cell communication (CCC) are critical for maintaining complex...
Cell–cell interactions (CCIs) and cell–cell communication (CCC) are critical for maintaining complex...
Cell–cell interactions (CCIs) and cell–cell communication (CCC) are critical for maintaining complex...
Cell-cell interactions are vital for numerous biological processes including development, differenti...
Cell-cell communication is crucial for development and tissue homeostasis in multicellular organisms...
Motivation Cell to cell communication is critical for all multicellular organisms, and single-cell s...
Complex biological systems are described as a multitude of cell-cell interactions (CCIs). Recent sin...
Cell-cell interactions are vital for numerous biological processes including development, differenti...
Summary: Tumor ecosystems are composed of multiple cell types that communicate by ligand-receptor in...
While methods for detecting single cell transcriptome and genome architecture have been established,...
Single-cell CRISPR screens enable the exploration of mammalian gene function and genetic regulatory ...
Abstract Background Cellular communication is an essential feature of multicellular organisms. Bindi...
Innate lymphoid cells (ILCs) consist of natural killer (NK) cells and non-cytotoxic ILCs that are br...
International audienceNetworks are powerful tools to represent and investigate biological systems. T...
Cell–cell interactions (CCIs) and cell–cell communication (CCC) are critical for maintaining complex...
Cell–cell interactions (CCIs) and cell–cell communication (CCC) are critical for maintaining complex...
Cell–cell interactions (CCIs) and cell–cell communication (CCC) are critical for maintaining complex...
Cell–cell interactions (CCIs) and cell–cell communication (CCC) are critical for maintaining complex...
Cell-cell interactions are vital for numerous biological processes including development, differenti...
Cell-cell communication is crucial for development and tissue homeostasis in multicellular organisms...
Motivation Cell to cell communication is critical for all multicellular organisms, and single-cell s...
Complex biological systems are described as a multitude of cell-cell interactions (CCIs). Recent sin...
Cell-cell interactions are vital for numerous biological processes including development, differenti...
Summary: Tumor ecosystems are composed of multiple cell types that communicate by ligand-receptor in...
While methods for detecting single cell transcriptome and genome architecture have been established,...
Single-cell CRISPR screens enable the exploration of mammalian gene function and genetic regulatory ...
Abstract Background Cellular communication is an essential feature of multicellular organisms. Bindi...
Innate lymphoid cells (ILCs) consist of natural killer (NK) cells and non-cytotoxic ILCs that are br...
International audienceNetworks are powerful tools to represent and investigate biological systems. T...