Increased plasma concentrations of angiotension II (Ang II) have been implicated in atherogenesis. To examine this relationship directly, we infused Ang II or vehicle for 1 month via osmotic minipumps into mature apoE–/– mice. These doses of Ang II did not alter arterial blood pressure, body weight, serum cholesterol concentrations, or distribution of lipoprotein cholesterol. However, Ang II infusions promoted an increased severity of aortic atherosclerotic lesions. These Ang II–induced lesions were predominantly lipid-laden macrophages and lymphocytes; moreover, Ang II promoted a marked increase in the number of macrophages present in the adventitial tissue underlying lesions. Unexpectedly, pronounced abdominal aortic aneurysms were presen...
Abdominal aortic aneurysm (AAA) is a devastating disease that exhibits permanent lumen expansion typ...
Objective To understand the anatomy and physiology of ascending aortic aneurysms in angiotensin II-i...
Background and Objective Recently, we demonstrated that angiotensin II (AngII)-infusion profoundly ...
Mechanisms responsible for atherosclerotic plaque development, destabilization, and rupture are stil...
Objective: This study determined whether hypercholesterolemia would contribute to both the initiatio...
Angiogenesis and inflammation are implicated in aortic aneurysm and atherosclerosis and regulated by...
1 We have demonstrated previously that infusion of angiotensin II (AngII) into hyperlipidemic mice a...
BackgroundWe explored the role of angiotensin II in determining the histomorphometric features of pl...
Understanding variations in size and pattern of development of angiotensin II (Ang II)-induced abdom...
Angiotensin II (Ang II) promotes development of ascending aortic aneurysms (AAs), but progression of...
Objective: Understanding variations in size and pattern of development of angiotensin II (Ang II)-in...
Angiotensin (Ang) A is formed by the decarboxylation of the N terminal residue of AngII. The present...
AngII (angiotensin II) induces atherosclerosis and AAAs (abdominal aortic aneurysms) through multipl...
Objective—We sought to define the temporal characteristics of angiotensin II (AngII)–induced abdomin...
Abdominal aortic aneurysms (AAAs) are characterized by a weakened vessel wall and a diameter 50% gre...
Abdominal aortic aneurysm (AAA) is a devastating disease that exhibits permanent lumen expansion typ...
Objective To understand the anatomy and physiology of ascending aortic aneurysms in angiotensin II-i...
Background and Objective Recently, we demonstrated that angiotensin II (AngII)-infusion profoundly ...
Mechanisms responsible for atherosclerotic plaque development, destabilization, and rupture are stil...
Objective: This study determined whether hypercholesterolemia would contribute to both the initiatio...
Angiogenesis and inflammation are implicated in aortic aneurysm and atherosclerosis and regulated by...
1 We have demonstrated previously that infusion of angiotensin II (AngII) into hyperlipidemic mice a...
BackgroundWe explored the role of angiotensin II in determining the histomorphometric features of pl...
Understanding variations in size and pattern of development of angiotensin II (Ang II)-induced abdom...
Angiotensin II (Ang II) promotes development of ascending aortic aneurysms (AAs), but progression of...
Objective: Understanding variations in size and pattern of development of angiotensin II (Ang II)-in...
Angiotensin (Ang) A is formed by the decarboxylation of the N terminal residue of AngII. The present...
AngII (angiotensin II) induces atherosclerosis and AAAs (abdominal aortic aneurysms) through multipl...
Objective—We sought to define the temporal characteristics of angiotensin II (AngII)–induced abdomin...
Abdominal aortic aneurysms (AAAs) are characterized by a weakened vessel wall and a diameter 50% gre...
Abdominal aortic aneurysm (AAA) is a devastating disease that exhibits permanent lumen expansion typ...
Objective To understand the anatomy and physiology of ascending aortic aneurysms in angiotensin II-i...
Background and Objective Recently, we demonstrated that angiotensin II (AngII)-infusion profoundly ...