The Inflammasome Sensor, NLRP3, Regulates CNS Inflammation and Demyelination via Caspase-1 and Interleukin-18
- Jha, Sushmita
- Srivastava, Siddharth Y.
- Brickey, W. June
- Iocca, Heather
- Toews, Arrel
- Morrison, James P.
- Chen, Vivian S.
- Gris, Denis
- Matsushima, Glenn K.
- Ting, Jenny P.Y.
Publication date
January 2010
DOIAbstract
Inflammation is increasingly recognized as an important contributor to a host of CNS disorders; however, its regulation in the brain is not well delineated. Nucleotide-binding domain, leucine-rich repeat, pyrin domain containing 3 (NLRP3) is a key component of the inflammasome complex, which also includes ASC (apoptotic speck-containing protein with a card) and procaspase-1. Inflammasome formation can be triggered by membrane P2
Add to ORKG