Human major histocompatibility complex class II-associated invariant chain gene promoter : functional analysis and in vitro protein/DNA interactions of constitutive and IFN-γ-induced expression

Major histocompatibility complex (MHC) class II-associated invariant chain (Ii) gene and the MHC class II molecules are physically and functionally associated within clans II-expressing cell types. These genes are generally co-expressed in various cell types and coordinately induced by cytokines such as interferon-γ (IFN-γ). Human Ii gene shares a regulatory mechanism with MHC class II genes via the X and Y cis-acting elements. Ii X and Y are required for constitutive expression in B lymphoid cell lines and for induction by IFN-γ in a glioblastoma cell line. The Servenius element (S) contributes 5-fold transcriptional activity to class II gene HLA-DRA and an S homologue has been implied in Ii gene regulation.Major histocompatibility complex (MHC) class II-associated invariant chain (Ii) gene and the MHC class II molecules are physically and functionally associated within clans II-expressing cell types. These genes are generally co-expressed in various cell types and coordinately induced by cytokines such as interferon-γ (IFN-γ). Human Ii gene shares a regulatory mechanism with MHC class II genes via the X and Y cis-acting elements. Ii X and Y are required for constitutive expression in B lymphoid cell lines and for induction by IFN-γ in a glioblastoma cell line. The Servenius element (S) contributes 5-fold transcriptional activity to class II gene HLA-DRA and an S homologue has been implied in Ii gene regulation