Vironome of Kaposi sarcoma associated herpesvirus-inflammatory cytokine syndrome in an AIDS patient reveals co-infection of human herpesvirus 8 and human herpesvirus 6A
- Tamburro, Kristen M.
- Yang, Dongmei
- Poisson, Jessica
- Fedoriw, Yuri
- Roy, Debasmita
- Lucas, Amy
- Sin, Sang-Hoon
- Malouf, Nadia
- Moylan, Vincent
- Damania, Blossom
- Moll, Stephan
- van der Horst, Charles
- Dittmer, Dirk P.
DOIAbstract
KSHV inflammatory cytokine syndrome (KICS) is a newly described condition characterized by systemic illness as a result of systemic, lytic KSHV infection. We used Illumina sequencing to establish the DNA vironome of blood from such a patient. It identified concurrent high-level viremia of human herpesvirus (HHV) 8 and 6a. The HHV8 plasma viral load was 5,300,000 copies/ml, which is the highest reported to date; this despite <5 skin lesions and no HHV8 associated lymphoma. This is the first report of systemic HHV6a/KSHV co-infection in a patient. It is the first whole genome KSHV sequence to be determined directly from patient plasma rather than cultured or biopsied tumor material. This case supports KICS as a new clinical entity associated ...
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