Differential Effects of Ethanol on Serum GABAergic 3α,5α/3α,5β Neuroactive Steroids in Mice, Rats, Cynomolgus Monkeys, and Humans
- Porcu, Patrizia
- O'Buckley, Todd K.
- Alward, Sarah E.
- Song, Soomin C.
- Grant, Kathleen A.
- De Wit, Harriet
- Leslie Morrow, A.
Publication date
January 2010
DOIAbstract
Acute ethanol administration increases plasma and brain levels of progesterone and deoxycorticosterone-derived neuroactive steroids (3α,5α)-3-hydroxypregnan-20-one (3α,5α-THP) and (3α,5α)-3,21-dihydroxypregnan-20-one (3α,5α-THDOC) in rats. However, little is known about ethanol effects on GABAergic neuroactive steroids in mice, non-human primates or humans. We investigated the effects of ethanol on plasma levels of 3α,5α- and 3α,5β-reduced GABAergic neuroactive steroids derived from progesterone, deoxycorticosterone, dehydroepiandrosterone and testosterone using gas chromatography-mass spectrometry
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