AbstractHuman embryonic stem cells (hESCs) derived from the pluripotent Inner cell mass (ICM) of the blastocyst are fundamental tools for understanding human development, yet are not identical to their tissue of origin. To investigate this divergence we compared the transcriptomes of genetically paired ICM and trophectoderm (TE) samples with three hESC lines: MAN1, HUES3 and HUES7 at similar passage. We generated inferred interactome networks using transcriptomic data unique to the ICM or TE, and defined a hierarchy of modules (highly connected regions with shared function). We compared network properties and the modular hierarchy and show that the three hESCs had limited overlap with ICM specific transcriptome (6%-12%). However this overla...
Background: Little is understood of the molecular mechanisms involved in the earliest cell fate deci...
Human embryonic stem cells (hESCs) have the potential to form any cell type in the body, making them...
BACKGROUND: The mechanisms responsible for the maintenance of pluripotency in human embryonic stem c...
AbstractHuman embryonic stem cells (hESCs) derived from the pluripotent Inner cell mass (ICM) of the...
Networks of interacting co-regulated genes distinguish the inner cell mass (ICM) from the different...
Networks of interacting co-regulated genes distinguish the inner cell mass (ICM) from the different...
STUDY QUESTION: What are the transcriptional changes occurring during the human embryonic stem cell ...
STUDY QUESTION: What are the transcriptional changes occurring during the human embryonic stem cell ...
STUDY QUESTION: What are the transcriptional changes occurring during the human embryonic stem cell ...
<div><p>Human embryonic stem cells (hESCs) have the potential to form any cell type in the body, mak...
Background: Little is understood of the molecular mechanisms involved in the earliest cell fate deci...
BACKGROUND: Little is understood of the molecular mechanisms involved in the earliest cell fate deci...
STUDY QUESTION: What are the transcriptional changes occurring during the human embryonic stem cell ...
STUDY QUESTION: What are the transcriptional changes occurring during the human embryonic stem cell ...
STUDY QUESTION: What are the transcriptional changes occurring during the human embryonic stem cell ...
Background: Little is understood of the molecular mechanisms involved in the earliest cell fate deci...
Human embryonic stem cells (hESCs) have the potential to form any cell type in the body, making them...
BACKGROUND: The mechanisms responsible for the maintenance of pluripotency in human embryonic stem c...
AbstractHuman embryonic stem cells (hESCs) derived from the pluripotent Inner cell mass (ICM) of the...
Networks of interacting co-regulated genes distinguish the inner cell mass (ICM) from the different...
Networks of interacting co-regulated genes distinguish the inner cell mass (ICM) from the different...
STUDY QUESTION: What are the transcriptional changes occurring during the human embryonic stem cell ...
STUDY QUESTION: What are the transcriptional changes occurring during the human embryonic stem cell ...
STUDY QUESTION: What are the transcriptional changes occurring during the human embryonic stem cell ...
<div><p>Human embryonic stem cells (hESCs) have the potential to form any cell type in the body, mak...
Background: Little is understood of the molecular mechanisms involved in the earliest cell fate deci...
BACKGROUND: Little is understood of the molecular mechanisms involved in the earliest cell fate deci...
STUDY QUESTION: What are the transcriptional changes occurring during the human embryonic stem cell ...
STUDY QUESTION: What are the transcriptional changes occurring during the human embryonic stem cell ...
STUDY QUESTION: What are the transcriptional changes occurring during the human embryonic stem cell ...
Background: Little is understood of the molecular mechanisms involved in the earliest cell fate deci...
Human embryonic stem cells (hESCs) have the potential to form any cell type in the body, making them...
BACKGROUND: The mechanisms responsible for the maintenance of pluripotency in human embryonic stem c...