BackgroundVentilator-induced lung injury (VILI) is characterized by vascular barrier dysfunction and suppression of alveolar fluid clearance (AFC). Obesity itself leads to chronic inflammation, which may initiate an injurious cascade to the lungs and simultaneously induce a protective feedback. In this study, we investigated the protective mechanism of obesity on VILI in a mouse model.MethodsThe VILI model was set up via 6-h mechanical ventilation with a high tidal volume. Parameters including lung injury score, STAT3/NFκB pathway, and AFC were assessed. Mice with diet-induced obesity were obtained by allowing free access to a high-fat diet since the age of 3 weeks. After a 9-week diet intervention, these mice were sacrificed at the age of ...
BackgroundObesity and chronic obstructive pulmonary disease (COPD) are prevailing worldwide, bringin...
Thoracic traumas with extra-thoracic injuries result in an immediate, complex host response. The imm...
Obese individuals are at greater risk for hospitalization and death from infection with the 2009 pan...
BackgroundVentilator-induced lung injury (VILI) is characterized by vascular barrier dysfunction and...
BackgroundVentilator-induced lung injury (VILI) is characterized by vascular barrier dysfunction and...
BackgroundVentilator-induced lung injury (VILI) is characterized by vascular barrier dysfunction and...
Objective: Obesity has a complex impact on acute respirator y distress syndrome patients, being asso...
Obesity is a risk factor for the development of acute respiratory distress syndrome (ARDS) but mecha...
Although obesity is implicated in numerous health complications leading to increased mortality, the ...
Obese patients are at higher risk of developing acute respiratory distress syndrome (ARDS); however,...
We previously reported that genetically obese mice exhibit innate airway hyperresponsiveness (AHR) a...
We have shown that obesity-associated attenuation of murine acute lung injury is driven, in part, by...
Obesity and respiratory disorders are major health problems. Obesity is becoming an emerging epidemi...
Vitamin D (VitD) has pleiotropic effects. VitD deficiency is closely involved with obesity and may c...
This study aims to evaluate the effects of a high-fat diet and mechanical ventilation on the pulmona...
BackgroundObesity and chronic obstructive pulmonary disease (COPD) are prevailing worldwide, bringin...
Thoracic traumas with extra-thoracic injuries result in an immediate, complex host response. The imm...
Obese individuals are at greater risk for hospitalization and death from infection with the 2009 pan...
BackgroundVentilator-induced lung injury (VILI) is characterized by vascular barrier dysfunction and...
BackgroundVentilator-induced lung injury (VILI) is characterized by vascular barrier dysfunction and...
BackgroundVentilator-induced lung injury (VILI) is characterized by vascular barrier dysfunction and...
Objective: Obesity has a complex impact on acute respirator y distress syndrome patients, being asso...
Obesity is a risk factor for the development of acute respiratory distress syndrome (ARDS) but mecha...
Although obesity is implicated in numerous health complications leading to increased mortality, the ...
Obese patients are at higher risk of developing acute respiratory distress syndrome (ARDS); however,...
We previously reported that genetically obese mice exhibit innate airway hyperresponsiveness (AHR) a...
We have shown that obesity-associated attenuation of murine acute lung injury is driven, in part, by...
Obesity and respiratory disorders are major health problems. Obesity is becoming an emerging epidemi...
Vitamin D (VitD) has pleiotropic effects. VitD deficiency is closely involved with obesity and may c...
This study aims to evaluate the effects of a high-fat diet and mechanical ventilation on the pulmona...
BackgroundObesity and chronic obstructive pulmonary disease (COPD) are prevailing worldwide, bringin...
Thoracic traumas with extra-thoracic injuries result in an immediate, complex host response. The imm...
Obese individuals are at greater risk for hospitalization and death from infection with the 2009 pan...