Schematic showing cellular location of BMAL1 targets downstream of CREB1 and estradiol generated using Ingenuity Pathway Analysis tools, with the addition of insulin and Fzd1 genes.

Gene names and symbols are given here and can be found with more detail in S16 Table. ATP-binding cassette subfamily A (Abca1, Abca8a, Abcg2); Activin A receptor (Acvr2a), ADAM metallopeptidase with thrombospondin type 1 (Adamts5, 18) and ADAM like decysin (Adamdec1), angiotensin II receptor (Agtr1b), A kinase anchoring protein (Akap9,13), angiopoietin (Angpt1), inorganic phosphate transporter (Ankh), amyloid beta precursor protein (APP), bone morphogenetic protein receptor type 1B (Bmpr1b), bisphosphate nucleotidase (Bpnt2) retinoic acid inducible (Brinp2), chromosome 2 open reading frame 88 (C2orf88), serum/glucocorticoid regulated kinase (Sgk3), calcium dependent secretion activator 2 (Cadps2), cellular communication network factor 3 (Ccn3), cadherins (Cdh8, 10,11, 13), cyclin dependent kinase (Cdk6, 14), CF transmembrane conductance regulator (Cftr), cholinergic receptor muscarinic 2 (Chrm2), cannabinoid receptor 1 (Cnr1), collagens (Col1a2, 3a1, 5a2, 11a1), complement C3d receptor 2 (Cr2), cAMP responsive element binding protein 1 (Creb1), cysteine rich transmembrane BMP regulator 1 (Crim1) crystallin zeta (Cryz), cystatin (Cst5), catenin alpha 2 (Ctnna2), chemokine receptor (Cxcr4), cytochrome P450 family (Cyp26b1, 51a1), DAB adaptor protein 2 (Dab2), dickkopf WNT signaling pathway inhibitor 2 (Dkk2), discs large MAGUK scaffold protein 2 (Dlg2), dynein light chain roadblock-type 2 (Dynlrb2), EGF like repeats and discoidin domains 3 (Edil), ephrin B2 (Efnb2), ectonucleotide pyrophosphatase (Ennpp2), erb-b2 receptor tyrosine kinase 4 (Erbb4), ELKS/RAB6-interacting/CAST family member 2 (Erc2), estrogen related receptor gamma (Esrrg), Fas associated via death domain (Fadd), fibroblast growth factor (Fgf9), four and a half LIM domains 2 (Fhl2), FERM domain containing 4B (Frmd4b), fucosyltransferase 8 (Fut8), polypeptide N-acetylgalactosaminyltransferase 7 (Galnt7), galanin receptor (Galr1), growth associated protein 43 (Gap43), glial cell derived neurotrophic factor (Gdnf), growth hormone receptor (Ghr), glutaminase (Gls), glutamate-ammonia ligase (Glul), G protein subunit gamma 12 (Gng12), glycerol-3-phosphate acyltransferase (Gpam), G protein-coupled receptor 63 (Gpr63), GPRIN family member 3 (Gprin3), growth factor receptor bound protein 10 (Grb10), glutamate ionotropic receptors (Gria1, Gria3, Grin2a), hyaluronan synthase 2 (Has2), histone deacetylase 5 (Hdac5), hepatocyte growth factor (Hgf), 15-hydroxyprostaglandin dehydrogenase (Hpgd), interleukin 15 (Il15), interleukin receptor (Il7r), inositol polyphosphate-4-phosphatase type II B (Inpp4b), insulin (Ins1), integrin subunit beta 1 (Itgb1), jagged canonical Notch ligand (Jag1), janus kinase 1 (Jak1), potassium voltage-gated channel (Kncab1, d2, d3, q5), kinase insert domain receptor (Kdr), Kruppel like factor 4 (Klf4), leptin (Lep), luteinizing hormone/choriogonadotropin receptor (Lhcgr), LIM domain 7 (Lmo7), lipoprotein lipase (Lpl), latent transforming growth factor beta binding protein 1 (Ltbp1), mab-21 like 1 (Mab21l1), mitotic arrest deficient 2 like 1 (Mad2l1), MAF bZIP transcription factor (Maf), membrane associated guanylate kinase (Magi1,2), mal, T cell differentiation protein 2 (Mal2), mitogen-activated protein kinase (Map2k6,k14), MyoD family inhibitor domain containing (Mdfic), MAM domain containing glycosylphosphatidylinositol anchor 1 (Mdga1), mesoderm specific transcript (Mest), myosin (Myo1b), myoferlin (Myof), NDUFA4 mitochondrial complex associated (Ndufa4), Nectin cell adhesion molecule (Nectin3), neural growth regulator (Negri), neuronal differentiation 6 (Neurod6), sodium/potassium transporting ATPase interacting (Nkain2), natriuretic peptide receptor 3 (Npr3), neuronal pentraxin 2 (Nptx2) neuropeptide Y (Npy) and receptor (Npr1r), nuclear receptors (Nr3c2-mineralcorticoid receptor; Nr5a2- liver receptor 1, an essential transcriptional regulator of lipid metabolism), neuropilin 2 (Nrp2), nudix hydrolase 7 (Nudt7), neurexophilin 1 (Nxph1), olfactomedin 4 (Ofm4), opioid receptor kappa 1 (Oprk1), PBX homeobox 1 (Pbx1), phosphodiesterase 1C (Pde1c), phospholipase A2 (Pla2g4a), plexin (Plxna2, a4), peripheral myelin protein 22 (Pmp22), PPARG coactivator 1 alpha (Ppargc1a), protein phosphatase 1 regulatory subunit 3B (Ppp1r3b), protein phosphatase 1 catalytic subunit alpha (Ppp3ca), prickle planar cell polarity protein 2 (Prickle2), prolactin (Prl8a2), prolactin receptor (Prlr), polypyrimidine tract binding protein 2 (Prbp2), prostaglandin E receptor (Ptger2,3,4), protein tyrosine kinase 2 (Ptk2), pentraxin (Ptx3), RALY RNA binding protein like (Ralyl), Rap2b, RB binding protein 8 (Rbbp8), retinol dehydrogenase 10 (Rdh10), regulator of G protein signaling (Rgs7, 18), roundabout guidance receptor 1 (Robo1), RP1 axonemal microtubule associated (Rp1), R-spondin 2 (Rspo2), receptor transporter protein 4 (Rtp4), RUNX1 partner transcriptional co-repressor 1 (Runx1t1), ryanodine receptor 2 (Ryr2), sphingosine-1-phosphate receptor 1 (S1pr1), Samhd1, SATB homeobox 1 (Satb1), selenoprotein P (Selnop), semaphorin 3A (Sema3a), shootin 1 (Shtn1), solute carrier (SLC1a3, 4a4, 6a11, 8a1), slit guidance ligand 2 (Slit2), sphingomyelin phosphodiesterase 1 (Smpd1), sushi, nidogen and EGF like domains 1 (Sned1), sortilin related VPS10 domain containing receptor 3 (Sorcs3), SPHK1 interactor, AKAP domain containing (Sphkap), SPARC-osteonectin (Spock3), sprouty related EVH1 domain, Steap1, containing 2 (Spred), serine/threonine kinase 3 (Stk3), tachykinin precursor 1 (Tac1), threonyl-tRNA synthetase 1 (Tars1), Tcb1d9, TBL1X receptor 1 (Tbl1xr1), tissue factor pathway inhibitor 2 (Tfpi2), thyroglobulin (Tg), thyroid hormone beta (Thrb), toll like receptor 4 (Tlr4), transmembrane (Tm4sf1, Tmeff2, Tmem74), TNF (Tnfsf11) and TNF receptor (Tnfrsf11b), tensin 3 (Tns3), translocation associated membrane protein 1 (Tram1), thyroid releasing hormone receptor (Trhr), tripartite motif containing 24 (Trim24), transcriptional repressor GATA binding 1 (Trps1), UDP glycosyltransferase 8 (Ugt8), vascular endothelial growth factor C (Vegfc), Wnt2, Wnt2b, Xkr4, zinc finger (Zbtb18, Zfhx3, Zfpm2, Zmat3).