qRT-PCR used to measure the IL6 mRNA level (A) and an ELISA used to measure secreted IL6 protein level (B) show that S100B levels inversely correlate with IL6 mRNA and secreted protein levels in WM115, WM793, WM1158, and SK-MEL-28 cells (n = 3; mean ± SD; ****, P < 0.0001). (C) Immunoblot analysis of p-STAT3 (Tyr705), total STAT3, and S100B in WM793, WM1158, and SK-MEL-28 melanoma cells showing that varying levels of S100B inversely correlate with p-STAT3 (Tyr705) levels (n = 3; mean ± SD; ****, P < 0.0001). (D) Immunoblot analysis of p-STAT3, total STAT3, and S100B in SK-MEL-28 cells upon S100B knockdown using transient siRNA showed significant increases in p-STAT3 versus the control siRNA as represented graphically (E) (n = 3, mean ± SD; ...
peer reviewedThe growth of melanocytes and many early stage melanoma cells can be inhibited by cytok...
peer reviewedInterleukin-6 (IL-6)-type cytokines lead to growth arrest of human A375 melanoma cells....
<p>(A) Immunohistochemistry for S100A8 in representative samples of tumor tissue and matching distal...
(A) qRT-PCR analysis was done to compare the IL6 mRNA levels in non-targeting scrambled and stable S...
(A) qRT-PCR of the relative S100B mRNA level in shSCR and shS100B WM115 cells (n = 3; mean ± SD; ***...
The overexpression of S100B in the WM1158 cells stably expressing a tetracycline-inducible S100B vec...
(A) The IL6 inhibitory antibody (0.15 μg/mL) prevented the autocrine activation of p-STAT3 upon addi...
Summary Introduction Cutaneous melanoma is an aggressive disease, which is recognised as the most co...
(A) qRT-PCR analysis of the IL6 mRNA and (B) ELISA of secreted IL6 protein in the media were perform...
Malignant melanoma is a cancer with increasing incidence worldwide with relevant socioeconomic impac...
The aim of the present work was to investigate the origin and half-life of endogenous S100B protein ...
Melanoma is the most malignant type of all skin cancer types. It causes over 75% of all skin cancer ...
Vitiligo is a chronic skin condition characterized by progressive depigmentation of the skin. S100B ...
<p>(<b>A</b>) Protein level of S100A8 was analyzed by Western blotting in Jurkat, HL-60, K562 and MV...
qRT-PCR was performed on STAT3 target genes CEBPD (A), SOCS3 (B), and SOCS1 (C) in shSCR and shS100B...
peer reviewedThe growth of melanocytes and many early stage melanoma cells can be inhibited by cytok...
peer reviewedInterleukin-6 (IL-6)-type cytokines lead to growth arrest of human A375 melanoma cells....
<p>(A) Immunohistochemistry for S100A8 in representative samples of tumor tissue and matching distal...
(A) qRT-PCR analysis was done to compare the IL6 mRNA levels in non-targeting scrambled and stable S...
(A) qRT-PCR of the relative S100B mRNA level in shSCR and shS100B WM115 cells (n = 3; mean ± SD; ***...
The overexpression of S100B in the WM1158 cells stably expressing a tetracycline-inducible S100B vec...
(A) The IL6 inhibitory antibody (0.15 μg/mL) prevented the autocrine activation of p-STAT3 upon addi...
Summary Introduction Cutaneous melanoma is an aggressive disease, which is recognised as the most co...
(A) qRT-PCR analysis of the IL6 mRNA and (B) ELISA of secreted IL6 protein in the media were perform...
Malignant melanoma is a cancer with increasing incidence worldwide with relevant socioeconomic impac...
The aim of the present work was to investigate the origin and half-life of endogenous S100B protein ...
Melanoma is the most malignant type of all skin cancer types. It causes over 75% of all skin cancer ...
Vitiligo is a chronic skin condition characterized by progressive depigmentation of the skin. S100B ...
<p>(<b>A</b>) Protein level of S100A8 was analyzed by Western blotting in Jurkat, HL-60, K562 and MV...
qRT-PCR was performed on STAT3 target genes CEBPD (A), SOCS3 (B), and SOCS1 (C) in shSCR and shS100B...
peer reviewedThe growth of melanocytes and many early stage melanoma cells can be inhibited by cytok...
peer reviewedInterleukin-6 (IL-6)-type cytokines lead to growth arrest of human A375 melanoma cells....
<p>(A) Immunohistochemistry for S100A8 in representative samples of tumor tissue and matching distal...