BLEEDING RISK ASSESSMENT IN PATIENTS WITH ACUTE NON ST ELEVATION MYOCARDIAL INFARCTION

Cilj istraživanja: Cilj istraživanja jest procjena rizika krvarenja CRUSADE bodovnomljestvicom u bolesnika s akutnim infarktom miokarda bez elevacije ST spojnice. Materijali i metode: U istraživanju je sudjelovalo ukupno 40 ispitanika kojima je dijagnosticiran NSTE-ACS a koji su bolnički liječeni u Kliničkom bolničkom centru Split. Istraživanje je provedeno od 1. veljače 2019. do 1. srpnja 2019 te su svi ispitanici potpisali su informirani pristanak. Uzorak krvi kod ispitanika sa NSTE-ACS-om prikupljen je isključivo pri prijemu. Od svih bolesnika smo prikupili opće i antropometrijske podatke koji uključuju dob, spol, tjelesnu visinu, tjelesna masu, opseg bokova te opseg struka. Uzorci krvi obradeni su u Laboratoriju za medicinsku kemiju i biokemiju Medicinskog fakulteta u Splitu, najviše 6 sati nakon uzorkovanja. Rezultati: Nije pronađena statistički značajna razlika u riziku krvarenja između ispitanika s višežilnom koronarnom bolesti i onih koji ne boluju od višežilne koronarne bolesti (P=0,630). Unutar cijele ispitivane populacije, pronađena je statistički značajna razlika u riziku krvarenja između ispitanika koji boluju od šećerne bolesti u odnosu na one koji ne boluju od šećerne bolesti (P=0,004). Prema dobivenim rezultatima, ispitanici koji boluju od šećerne bolesti imaju veći rizik za krvarenje. Isto tako, pronađena je statistički značajna razlika u riziku krvarenja u ispitanika koji su tretirani PCI-jem i u onih koji nisu tretirani PCI-jem (P=0,004) prema kojoj ispitanici tretirani PCI-jem imaju manji rizik za krvarenje. Zaključak: Podjednak rizik krvarenja imaju ispitanici s dijagnozom NSTEMI-ja koji imaju višežilnu koronarnu bolest te ispitanici koji od višežilne koronarne bolesti ne boluju. Ispitanici s dijagnozom NSTEMI-ja koji boluju od šećerne bolesti imaju veći rizik krvarenja, dok ispitanici s istom dijagnozom kojima je provedena PCI imaju manji rizik krvarenja.Aim of the study: The aim of the study was to assess the risk of bleeding with CRUSADE score in patients with acute non ST elevation myocardial infarction (NSTEMI). Materials and methods: A total of 40 subjects diagnosed with NSTEMI, who were hospitalized at the University Hospital of Split, participated in the study. The survey was conducted from February 1, 2019, to July 1, 2019, and all respondents signed an informed consent. A blood sample in subjects with NSTE-ACS was collected exclusively at admission. From all patients, we collected general and anthropometric data that included age, sex, body height, body weight, hip circumference, and waist circumference. Blood samples were processed in the Laboratory for Medical Chemistry and Biochemistry of the Medical Faculty in Split, no more than 6 hours after sampling. Results: No statistically significant difference in bleeding risk was found between subjects with multivessel disease and those not suffering from multivessel disease (P = 0.630). Within the entire study population, a statistically significant difference in bleeding risk was found between subjects with diabetes mellitus versus those without diabetes mellitus (P = 0.004). According to the results obtained, subjects suffering from diabetes mellitus have a higher risk of bleeding. Likewise, a statistically significant difference was found in the risk of bleeding in subjects treated with percutaneous coronary intervention (PCI) and in those not treated with PCI (P = 0.004) according to which subjects treated with PCI had a lower risk of bleeding. Conclusion: Equally at risk of bleeding are subjects diagnosed with NSTEMI who have multivessel disease and subjects who do not suffer from multivessel disease. Subjects diagnosed with NSTEMI suffering from diabetes mellitus have a higher risk of bleeding, while subjects with the same diagnosis who underwent PCI have a lower risk of bleeding