Computer-Aided Diagnosis of Low Grade Endometrial Stromal Sarcoma (LGESS)

Low grade endometrial stromal sarcoma (LGESS) is rare form of cancer, account- ing for about 0.2% of all uterine cancer cases. Approximately 75% of LGESS patients are initially misdiagnosed with leiomyoma, which is a type of benign tumor that is also known as fibroids. In this research, uterine tissue biopsy images of potential LGESS patients are preprocessed using segmentation and staining normalization algorithms. A wide variety of classic machine learning and leading deep learning models are then applied to classify tissue images as either benign or cancerous. For classic techniques, the highest classification accuracy we attain is 85%, while our best deep learning model achieves an accuracy of 87%. These results clearly indicate that properly trained learning algorithms can play a useful role in the diagnosis of LGESS