Depression and cardiovascular disease progression: Epidemiology, mechanisms and treatment

Depression and coronary heart disease (CHD) are the two strongest contributors to the global burden of disease.1 Both disorders are common, and while cardiovascular disease is an important factor directly contributing to mortality, depression is primarily associated with decreased health-related quality of life,2 and imposes a significant economic burden on society.3 However, there are also signs that depression may contribute to higher mortality rates, perhaps due to its association with somatic disease, and in particular CHD