Long-Term Morbidity and Health After Early Menopause Due to Oophorectomy in Women at Increased Risk of Ovarian Cancer: Protocol for a Nationwide Cross-Sectional Study With Prospective Follow-Up (HARMOny Study)
- Terra, L.
- Hooning, M.J.
- Heemskerk-Gerritsen, B.A.
- Beurden, M. van
- Lennep, J.E.Roeters van
- Doorn, H.C. van
- de Hullu, J.A.
- Mom, C.
- Dorst, E.B.L. van
- Mourits, M.J.E.
- Slangen, B.F.M.
- Gaarenstroom, K.N.
- Zillikens, M.C.
- Leiner, T.
- Kolk, L. van der
- Collee, M.
- Wevers, M.R.
- Ausems, M.
- Engelen, K. van
- Berger, L.P.V.
- Asperen, C.J. van
- Gomez-Garcia, E.B.
- Beek, I. van de
- Rookus, Matti A.
- Hauptmann, M.
- Bleiker, E.M.A.
- Schagen, S.B.
- Aaronson, N.K.
- Maas, A.H.E.M.
- Leeuwen, F.E. van
DOIAbstract
BACKGROUND: BRCA1/2 mutation carriers are recommended to undergo risk-reducing salpingo-oophorectomy (RRSO) at 35 to 45 years of age. RRSO substantially decreases ovarian cancer risk, but at the cost of immediate menopause. Knowledge about the potential adverse effects of premenopausal RRSO, such as increased risk of cardiovascular disease, osteoporosis, cognitive dysfunction, and reduced health-related quality of life (HRQoL), is limited. OBJECTIVE: The aim of this study is to assess the long-term health effects of premenopausal RRSO on cardiovascular disease, bone health, cognitive functioning, urological complaints, sexual functioning, and HRQoL in women with high familial risk of breast or ovarian cancer. METHODS: We will conduct a mult...
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