Great strides have been made in understanding and treating hepatitis C virus (HCV) thanks to the development of various experimental systems including cell-culture-proficient HCV, the HCV pseudoparticle system and soluble envelope glycoproteins. The HCV pseudoparticle (HCVpp) system is a platform used extensively in studies of cell entry, screening of novel entry inhibitors, assessing the phenotypes of clinically observed E1 and E2 glycoproteins and, most pertinently, in characterizing neutralizing antibody breadth induced upon vaccination and natural infection in patients. Nonetheless, some patient-derived clones produce pseudoparticles that are either non-infectious or exhibit infectivity too low for meaningful phenotyping. The mechanisms...
The humoral response to hepatitis C virus (HCV) may contribute to controlling infection. We previous...
International audienceHepatitis C virus (HCV) productively infects hepatocytes. Virion surface glyco...
Development of full-length hepatitis C virus (HCV) RNAs replicating efficiently and producing infect...
Great strides have been made in understanding and treating hepatitis C virus (HCV) thanks to the dev...
Retrovirus pseudotypes are a highly tractable model used to study the entry pathways of enveloped vi...
The study of hepatitis C virus (HCV), a major cause of chronic liver disease, has been hampered by t...
The study of hepatitis C virus (HCV), a major cause of chronic liver disease, has been hampered by t...
Because of the lack of a robust cell culture system, relatively little is known about the molecular ...
We recently reported that retroviral pseudotypes bearing the hepatitis C virus (HCV) strain H and Co...
Retrovirus pseudotypes are a highly tractable model used to study the entry pathways of enveloped vi...
Despite significant advances in the treatment of hepatitis C virus (HCV) infection, the need to deve...
AbstractThe genome of hepatitis C virus (HCV) encodes two envelope glycoproteins (E1 and E2), which ...
AbstractThe envelope proteins of hepatitis C virus (HCV) are the likely targets of neutralizing anti...
The envelope glycoprotein E2 of hepatitis C virus (HCV) is the target of neutralizing antibodies and...
Hepatitis C virus (HCV) is a major cause of chronic hepatitis infection worldwide. It leads to chron...
The humoral response to hepatitis C virus (HCV) may contribute to controlling infection. We previous...
International audienceHepatitis C virus (HCV) productively infects hepatocytes. Virion surface glyco...
Development of full-length hepatitis C virus (HCV) RNAs replicating efficiently and producing infect...
Great strides have been made in understanding and treating hepatitis C virus (HCV) thanks to the dev...
Retrovirus pseudotypes are a highly tractable model used to study the entry pathways of enveloped vi...
The study of hepatitis C virus (HCV), a major cause of chronic liver disease, has been hampered by t...
The study of hepatitis C virus (HCV), a major cause of chronic liver disease, has been hampered by t...
Because of the lack of a robust cell culture system, relatively little is known about the molecular ...
We recently reported that retroviral pseudotypes bearing the hepatitis C virus (HCV) strain H and Co...
Retrovirus pseudotypes are a highly tractable model used to study the entry pathways of enveloped vi...
Despite significant advances in the treatment of hepatitis C virus (HCV) infection, the need to deve...
AbstractThe genome of hepatitis C virus (HCV) encodes two envelope glycoproteins (E1 and E2), which ...
AbstractThe envelope proteins of hepatitis C virus (HCV) are the likely targets of neutralizing anti...
The envelope glycoprotein E2 of hepatitis C virus (HCV) is the target of neutralizing antibodies and...
Hepatitis C virus (HCV) is a major cause of chronic hepatitis infection worldwide. It leads to chron...
The humoral response to hepatitis C virus (HCV) may contribute to controlling infection. We previous...
International audienceHepatitis C virus (HCV) productively infects hepatocytes. Virion surface glyco...
Development of full-length hepatitis C virus (HCV) RNAs replicating efficiently and producing infect...