Advances in science and technology have significantly improved our quality of life over the past decades. For example, wireless communication systems have evolved from basic voice services to delivering high-definition video for entertainment or business conferences at an accelerating pace. Furthermore, progress in cyber-physical systems has led to the development of brain-computer interfaces and wireless body area networks with the vision of advanced pervasive healthcare, anytime and anywhere. The primary motivation of this dissertation is to improve the performance of the next-generation multi-service communication and medical cyber-physical systems. The research has been concentrated in physical (PHY)/medium access control (MAC) layer as...