The NAD-dependent deacetylase SIRT1 regulates several factors involved in stress response and cell survival but its function in cancer is largely unknown. Research suggests that SIRT1 influences several transcription factors and molecules that are important components of pathways often deregulated in cancer. Our experiments have shown that SIRT1 knock down by short hairpin RNA accelerates tumor xenograft formation by HCT116 colon cancer cells, whereas SIRT1 overexpression inhibits tumor formation. We have also found that, pharmacological inhibition of SIRT1 stimulates cell proliferation under conditions of growth factor deprivation suggesting a tumor suppressive function of SIRT1. Paradoxically, SIRT1 inhibition sensitizes the same cells to...
Sirtuins (SIRTs), class III histone deacetylases, are differentially expressed in several human canc...
Hongfeng Yuan,1 Leila Su,2 WenYong Chen1 1Department of Cancer Biology, 2Department of Molecular Med...
Sirtuin 1 (SIRT1), an NAD(+)-dependent histone/protein deacetylase, has multifaceted functions in va...
The NAD-dependent deacetylase SIRT1 regulates several factors involved in stress response and cell s...
Sirtuins, commonly referred to as SIRTs, are a family of seven mammalian NAD+-dependent deacetylases...
Background The class III histone deacetylase SIRT1 is a nicotinamide adenine dinucleotide (NAD(+))-d...
Background The class III histone deacetylase SIRT1 is a nicotinamide adenine dinucleotide (NAD(+))-d...
Sirtuins (SIRT1-7) are a highly conserved family of NADþ-dependent enzymes that control the activity...
[eng] The sirtuin protein family has emerged as important regulators of diverse pathological events,...
SIRT1, the most conserved mammalian NAD+-dependent protein deacetylase, plays a vital role in the re...
Sirtuin 1 (SIRT1) is a class III histone/protein deacetylase, and its activation status has been wel...
Sirtuin 1 (SIRT1) is a class III histone/protein deacetylase, and its activation status has been wel...
SIRT1, the most conserved mammalian NAD+-dependent protein deacetylase, plays a vital role in the re...
Sirtuin 1 (SIRT1) has been reported to have diverse roles in various biological processes through de...
The lysyl deacetylase SIRT1 acts as a metabolic sensor in adjusting metabolic imbalance. To explore ...
Sirtuins (SIRTs), class III histone deacetylases, are differentially expressed in several human canc...
Hongfeng Yuan,1 Leila Su,2 WenYong Chen1 1Department of Cancer Biology, 2Department of Molecular Med...
Sirtuin 1 (SIRT1), an NAD(+)-dependent histone/protein deacetylase, has multifaceted functions in va...
The NAD-dependent deacetylase SIRT1 regulates several factors involved in stress response and cell s...
Sirtuins, commonly referred to as SIRTs, are a family of seven mammalian NAD+-dependent deacetylases...
Background The class III histone deacetylase SIRT1 is a nicotinamide adenine dinucleotide (NAD(+))-d...
Background The class III histone deacetylase SIRT1 is a nicotinamide adenine dinucleotide (NAD(+))-d...
Sirtuins (SIRT1-7) are a highly conserved family of NADþ-dependent enzymes that control the activity...
[eng] The sirtuin protein family has emerged as important regulators of diverse pathological events,...
SIRT1, the most conserved mammalian NAD+-dependent protein deacetylase, plays a vital role in the re...
Sirtuin 1 (SIRT1) is a class III histone/protein deacetylase, and its activation status has been wel...
Sirtuin 1 (SIRT1) is a class III histone/protein deacetylase, and its activation status has been wel...
SIRT1, the most conserved mammalian NAD+-dependent protein deacetylase, plays a vital role in the re...
Sirtuin 1 (SIRT1) has been reported to have diverse roles in various biological processes through de...
The lysyl deacetylase SIRT1 acts as a metabolic sensor in adjusting metabolic imbalance. To explore ...
Sirtuins (SIRTs), class III histone deacetylases, are differentially expressed in several human canc...
Hongfeng Yuan,1 Leila Su,2 WenYong Chen1 1Department of Cancer Biology, 2Department of Molecular Med...
Sirtuin 1 (SIRT1), an NAD(+)-dependent histone/protein deacetylase, has multifaceted functions in va...