During hematopoiesis, multilineage progenitor cells and the precursors are committed to individual hematopoietic lineages. In normal myelopoiesis, the immature myeloid cells (IMCs) differentiate into macrophages, neutrophils or dendritic cells. However, under tumor burden, these IMCs differentiate into myeloid derived suppressor cells (MDSCs) result in an up-regulation of immune suppressive factors and pro-tumor effect. The development of normal or malignant is tightly controlled by endogenous signals such as transcription factors and epigenetic regulations. HDAC11 is the newest identified members of the histone deacetylase (HDAC) family. Previous study in our group had identified HDAC11 as a negative regulator of interleukin 10 (IL-10) pro...
Histone acetyltransferases (HATs) and histone deacetylases (HDACs) counteract with each other to reg...
AbstractMouse bone marrow stromal stem/progenitor cells (BMSCs, also known as bone marrow-derived me...
The generation of B cells is a complex process requiring several cellular transitions, including cel...
During hematopoiesis, multilineage progenitor cells and the precursors are committed to individual h...
During hematopoiesis, multilineage progenitor cells and the precursors are committed to individual h...
New therapies are desperately needed to improve patient response and prevent patient relapse in lymp...
Cancer represents the second leading cause of death in the United States. For many malignancies, cur...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
Numerous studies have highlighted the role of post-translational modifications in the regulation of ...
Histone deacetylase 2 (HDAC2) is overexpressed or mutated in several disorders such as hematological...
Histone deacetylases (HDAC) 1 and 2 are highly similar enzymes that help regulate chromatin structur...
The treatment options for advanced cutaneous T-cell lymphoma (CTCL) are limited because of its uncle...
Histone deacetylases (HDACs) are key mediators of gene expression and, thus, major regulators of cel...
Mouse bone marrow stromal stem/progenitor cells (BMSCs, also known as bone marrow-derived mesenchyma...
Histone deacetylase inhibitors have demonstrated activity in hematological and solid malignancies. V...
Histone acetyltransferases (HATs) and histone deacetylases (HDACs) counteract with each other to reg...
AbstractMouse bone marrow stromal stem/progenitor cells (BMSCs, also known as bone marrow-derived me...
The generation of B cells is a complex process requiring several cellular transitions, including cel...
During hematopoiesis, multilineage progenitor cells and the precursors are committed to individual h...
During hematopoiesis, multilineage progenitor cells and the precursors are committed to individual h...
New therapies are desperately needed to improve patient response and prevent patient relapse in lymp...
Cancer represents the second leading cause of death in the United States. For many malignancies, cur...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
Numerous studies have highlighted the role of post-translational modifications in the regulation of ...
Histone deacetylase 2 (HDAC2) is overexpressed or mutated in several disorders such as hematological...
Histone deacetylases (HDAC) 1 and 2 are highly similar enzymes that help regulate chromatin structur...
The treatment options for advanced cutaneous T-cell lymphoma (CTCL) are limited because of its uncle...
Histone deacetylases (HDACs) are key mediators of gene expression and, thus, major regulators of cel...
Mouse bone marrow stromal stem/progenitor cells (BMSCs, also known as bone marrow-derived mesenchyma...
Histone deacetylase inhibitors have demonstrated activity in hematological and solid malignancies. V...
Histone acetyltransferases (HATs) and histone deacetylases (HDACs) counteract with each other to reg...
AbstractMouse bone marrow stromal stem/progenitor cells (BMSCs, also known as bone marrow-derived me...
The generation of B cells is a complex process requiring several cellular transitions, including cel...