Add to ORKGThe subject invention concerns compounds having activity as inhibitors of proteasomes and methods of using the subject compounds. In one embodiment, a compound of the invention has the chemical structure shown in formula I: or a pharmaceutically acceptable salt or hydrate thereof. In another embodiment, a compound of the invention has the chemical structure shown in formula II: or a pharmaceutically acceptable salt or hydrate thereof
International audienceProteasome inhibition is a promising strategy for treating cancers. Herein, we...
The problem of finding targeted medicine is a central problem in chemotherapy. From this point of vi...
The subject invention concerns materials and methods for inhibiting the Akt/PKB pathway. In one embo...
The subject invention concerns compounds having activity as inhibitors of proteasomes and methods of...
International audienceIn cells, protein degradation is a key pathway for the destruction of abnormal...
Abstract: Proteasome inhibition is a therapeutic concept of current interest in anticancer research....
Proteins are the basic building blocks of the human body. Most proteins, after fulfilling their func...
The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of ...
The ubiquitin-proteasome system plays an important role in cellular homeostasis and also has a criti...
The proteasome is a multicatalytic protease and the principal non-lysosomal proteolytic system in al...
Abstract Proteasomes are multicatalytic protease complexes in the cell, involved in the non-lysosoma...
Most patients diagnosed with cancer will receive systematic chemotherapy at some point during their ...
International audienceProteasome inhibition is a promising strategy for treating cancers. Herein, we...
The problem of finding targeted medicine is a central problem in chemotherapy. From this point of vi...
The subject invention concerns materials and methods for inhibiting the Akt/PKB pathway. In one embo...
The subject invention concerns compounds having activity as inhibitors of proteasomes and methods of...
International audienceIn cells, protein degradation is a key pathway for the destruction of abnormal...
Abstract: Proteasome inhibition is a therapeutic concept of current interest in anticancer research....
Proteins are the basic building blocks of the human body. Most proteins, after fulfilling their func...
The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of ...
The ubiquitin-proteasome system plays an important role in cellular homeostasis and also has a criti...
The proteasome is a multicatalytic protease and the principal non-lysosomal proteolytic system in al...
Abstract Proteasomes are multicatalytic protease complexes in the cell, involved in the non-lysosoma...
Most patients diagnosed with cancer will receive systematic chemotherapy at some point during their ...
International audienceProteasome inhibition is a promising strategy for treating cancers. Herein, we...
The problem of finding targeted medicine is a central problem in chemotherapy. From this point of vi...
The subject invention concerns materials and methods for inhibiting the Akt/PKB pathway. In one embo...