Three-dimensional Ultrasound Imaging For Quantifying Knee Cartilage Volume

Arthritis is the most common chronic health condition in Canada, with the most common form being osteoarthritis (OA). There is a great clinical need for an objective imaging-based point-of-care tool to assess OA status, progression, and response to treatment. This thesis aims to validate a handheld mechanical three-dimensional (3D) ultrasound (US) device against the current clinical standard of magnetic resonance imaging (MRI) for quantifying femoral articular cartilage (FAC) volume. Knee images of 25 healthy volunteers were acquired using 3D US and 3.0 Tesla MRI scans. Two raters manually segmented the trochlear FAC during separate sessions to assess intra- and inter-rater reliabilities. The results demonstrated that 3D US has excellent reliability and strong concurrent validity with MRI for measuring healthy FAC volume. 3D US is a promising, inexpensive, and widely accessible imaging modality that will enable clinicians and researchers to obtain additional information without added complexity or discomfort to patients