Empirical finance has growingly relied on statistical methods to draw inferences. Such finance applications require tailoring the methods to particular problems, especially when the underlying assumptions are violated in the data. This dissertation studies the development and application of statistical methodologies to address empirical problems in the contexts of empirical asset pricing, household finance and investments. The dissertation consists of four chapters. The first chapter gives an overview of the empirical problems and associated statistical issues for three different finance settings: stock return predictability, house price comovement and mutual fund performance. It also briefly outlines the main contribution of this dissertat...