Attention-deficit/hyperactivity disorder in children and adolescents: An event-related potential study of working memory

Working memory (WM) impairments have been frequently observed as an important feature of attention-deficit/hyperactivity disorder (ADHD). Event-related potential (ERP) differences between ADHD and healthy controls (HC) would be expected during WM task performance. Especially, the so-called slow wave (SW), which is related to the retention process, might present amplitude differences in ADHD. In this ERP study participated twenty-nine ADHD children and adolescents and thirty-four HC. WM performance was assessed using the Working Memory Test Battery for Children (WMTB-C), and ERPs were analyzed with a Delayed Match-To-Sample (DMTS) task. ADHD sample showed worse behavioral performance in both WMTB-C and DMTS task, and higher SW amplitude during the retention phase of the DMTS task. Additionally, the principal component analysis indicated that the scores on the component explaining the centro-parietal SW were significantly different between ADHD subjects and HC. The observed impaired neurophysiological activity during the encoding and retention periods in ADHD, which would be the origin of the behavioral deficits in WM task performance, might be reflecting a delayed maturation of the neural processes underlying the centro-parietal SW.Ministry of Science and InnovationSpanish Government [PSI2013-47506-R]Consejeria de Innovacion, Ciencia y Empresa of the Junta de AndaluciaJunta de Andalucia [PSI2016-80059-R]Janssen-CilagJohnson & JohnsonJohnson & Johnson USAJanssen Biotech Inc