The effect of bioactive spice compounds on obesity

Pretilost je globalni zdravstveni problem koji povećava rizik od učestalosti dijabetesa, kardiovaskularnih bolesti, hipertenzije i tumora. Dva čimbenika koji uzrokuju pretilost su povećana masa masnog tkiva i povećana sekrecija patogenih produkata uzrokovanih povećanim masnim stanicama. Farmakološka terapija pokazivala je brojne štetne učinke na zdravlje pa se tražio novi, alternativni oblik terapije. Brojna istraživanja pokazala su djelotvoran učinak bioaktivnih sastojaka začina u prevenciji pretilosti i nekih oblika terapija u liječenju pretilosti i s njom povezanih metaboličkih poremećaja. Bioaktivni sastojci začina su reducirali akumulaciju lipida u masnim stanicama i masnom tkivu regulacijom ekspresije transkripcijskih faktora. Cilj ovog rada bio je istražiti razne mehanizme začina u modelima stanica, životinja i ljudi u prevenciji pretilosti. Pregled literature pokazao da su mehanizmi nekih bioaktivnih spojeva još u fazama istraživanja, ali ovaj oblik terapije ima velik potencijal u liječenju i prevenciji pretilosti.Obesity is a global health problem that increases the incidence of diabetes, cardiovascular diseases, hypertension and cancer. Two factors that cause obesity are increased adipose tissue mass and increased secretion of pathogenic products caused by increased fat cells. Pharmacological therapy showed a number of harmful effects on health, so a new alternative form of therapy was sought. Numerous studies have shown beneficial effect of bioactive compounds of spices in the prevention of obesity and some forms of therapies in the treatment of obesity and related metabolic disorders. Bioactive spice compounds reduced lipid accumulation in adipose cells and adipose tissue by regulating the expression of transcription factors. The aim of this study was to investigate various mechanisms of spices in cell models,animal models and human models in prevention of obesity. A review of literature has shown that the mechanisms of some bioactive compounds are still in research stages, but this form of therapy has great potential in the treatment and prevention of obesity