Management of children and young people with idiopathic pituitary stalk thickening, central diabetes insipidus, or both: a national clinical practice consensus guideline.
- Cerbone, Manuela
- Visser, Johannes
- Bulwer, Chloe
- Ederies, Ashraf
- Vallabhaneni, Kirtana
- Ball, Stephen
- Kamali-Asl, Ian
- Grossman, Ashley
- Gleeson, Helena
- Korbonits, Márta
- Nanduri, Vasanta
- Tziaferi, Vaya
- Jacques, Tom
- Spoudeas, Helen A.
DOIAbstract
Unexplained or idiopathic pituitary stalk thickening or central diabetes insipidus not only harbours rare occult malignancies in 40% of cases but can also reflect benign congenital defects. Between 2014 and 2019, a multidisciplinary, expert national guideline development group in the UK systematically developed a management flowchart and clinical practice guideline to inform specialist care and improve outcomes in children and young people (aged <19 years) with idiopathic pituitary stalk thickening, central diabetes insipidus, or both. All such cases of idiopathic pituitary stalk thickening and central diabetes insipidus require dynamic pituitary function testing, specialist pituitary imaging, measurement of serum ?-human chorionic gonadotr...
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