Background: Inhibition of the epithelial sodium channel (ENaC) in cystic fibrosis (CF) airways provides a mutation-agnostic approach that could improve mucociliary clearance in all CF patients. BI 1265162 is an ENaC inhibitor with demonstrated preclinical efficacy and safety already demonstrated in humans. Objective: We present results from BALANCE-CF™ 1, a Phase II, placebo-controlled, randomised, double-blind study of four dose levels of BI 1265162 versus placebo for 4 weeks on top of standard of care in adults and adolescents with CF. Results: Initially, 28 randomised subjects (n=14 each BI 1265162 200 µg BID, placebo BID) were assessed at an interim futility analysis. Compared with placebo, numerical changes of –0.8% (95%CI –6.6, 4.9) i...
We assessed the short-term efficacy and safety of aztreonam lysine for inhalation (AZLI [an aerosoli...
Background: Inhaled antibiotics are standard of care for persons with cystic fibrosis (CF) and chron...
RationaleFor patients with cystic fibrosis (CF), the use of inhaled antibiotics has become standard ...
Abstract Background Lancovutide activates a chloride channel (TMEM-16A) other than the cystic fibros...
AbstractBackgroundIt is hypothesized that a CXCR2 receptor antagonist would inhibit the recruitment ...
The epithelial Na+ channel (ENaC) is a key regulator of the volume of airway surface liquid (ASL) an...
Background: Cystic fibrosis (CF) is a chronic, life-limiting disease caused by mutations in the CF t...
The epithelial Na+ channel, ENaC, is a key regulator of the volume of airway surface liquid (ASL) in...
RATIONALE: For patients with cystic fibrosis (CF), the use of inhaled antibiotics has become standar...
Inhaled alpha1-proteinase inhibitor (PI) is known to reduce neutrophil elastase burden in some patie...
AbstractRationaleDenufosol stimulates chloride secretion independent of the chloride channel which i...
RATIONALE:In cystic fibrosis (CF) a reduction in airway surface liquid (ASL) height compromises muco...
Lung health relies on effective mucociliary clearance and innate immune defence mechanisms. In cysti...
BACKGROUND: MRT5005, a codon-optimized CFTR mRNA, delivered by aerosol in lipid nanoparticles, was d...
In cystic fibrosis (CF) lungs, epithelial Na+ channel (ENaC) hyperactivity causes a reduction in air...
We assessed the short-term efficacy and safety of aztreonam lysine for inhalation (AZLI [an aerosoli...
Background: Inhaled antibiotics are standard of care for persons with cystic fibrosis (CF) and chron...
RationaleFor patients with cystic fibrosis (CF), the use of inhaled antibiotics has become standard ...
Abstract Background Lancovutide activates a chloride channel (TMEM-16A) other than the cystic fibros...
AbstractBackgroundIt is hypothesized that a CXCR2 receptor antagonist would inhibit the recruitment ...
The epithelial Na+ channel (ENaC) is a key regulator of the volume of airway surface liquid (ASL) an...
Background: Cystic fibrosis (CF) is a chronic, life-limiting disease caused by mutations in the CF t...
The epithelial Na+ channel, ENaC, is a key regulator of the volume of airway surface liquid (ASL) in...
RATIONALE: For patients with cystic fibrosis (CF), the use of inhaled antibiotics has become standar...
Inhaled alpha1-proteinase inhibitor (PI) is known to reduce neutrophil elastase burden in some patie...
AbstractRationaleDenufosol stimulates chloride secretion independent of the chloride channel which i...
RATIONALE:In cystic fibrosis (CF) a reduction in airway surface liquid (ASL) height compromises muco...
Lung health relies on effective mucociliary clearance and innate immune defence mechanisms. In cysti...
BACKGROUND: MRT5005, a codon-optimized CFTR mRNA, delivered by aerosol in lipid nanoparticles, was d...
In cystic fibrosis (CF) lungs, epithelial Na+ channel (ENaC) hyperactivity causes a reduction in air...
We assessed the short-term efficacy and safety of aztreonam lysine for inhalation (AZLI [an aerosoli...
Background: Inhaled antibiotics are standard of care for persons with cystic fibrosis (CF) and chron...
RationaleFor patients with cystic fibrosis (CF), the use of inhaled antibiotics has become standard ...