Invasive lobular carcinoma: clinicopathological features and subtypes
- Sabine Danzinger
- Nora Hielscher
- Miriam Izsó
- Johanna Metzler
- Carmen Trinkl
- Christian Pfeifer
- Kristina Tendl-Schulz
- Christian F. Singer
DOIAbstract
Objective To analyze the characteristics of invasive lobular carcinoma (ILC) compared with invasive ductal carcinoma (IDC) and to investigate the impact of histology on axillary lymph node (ALN) involvement in luminal A subtype tumors. Methods We retrospectively analyzed patients diagnosed with ILC or IDC from 2012 to 2016 who underwent surgery. Patients constituted 493 primary early breast cancer cases (82 ILC; 411 IDC). Results Compared with IDC, ILC tumors were significantly more likely to be grade 2, estrogen receptor- (ER) positive (+), have a lower proliferation rate (Ki67 <14%), and a higher pathological T stage (pT2–4). The luminal A subtype was significantly more common in ILC compared with IDC. In a multivariate regression model, ...
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