Recently, accumulating evidence has supported that circular RNA (circRNA) plays important roles in tumorigenesis by regulating gene expression at transcriptional and post-transcriptional levels. Expression of circRNAs can be epigenetically silenced by DNA methylation; however, the underlying regulatory mechanisms of circRNAs by DNA methylation remains largely unknown. We explored this regulation in hepatocellular carcinoma (HCC) using genome-wide DNA methylation and RNA sequencing data of the primary tumor and matched adjacent normal tissues from 20 HCC patients. Our pipeline identified 1012 upregulated and 747 downregulated circRNAs (collectively referred to as differentially expressed circRNAs, or DE circRNAs) from HCC RNA-seq data. Among...
Abstract Circular RNAs (circRNAs), a novel type of non-coding RNAs (ncRNAs), have a covalently close...
Circular RNA (circRNA) can participate in various biological processes, including tumorigenesis, thr...
Pathologic alterations in epigenetic regulation have long been considered a hallmark of many cancers...
Background. Previous studies, including ours, have examined the regulation of microRNAs (miRNAs) by ...
Abstract At present, as hotspot members of the noncoding RNA network, circular RNAs (circRNAs) with ...
Noncoding RNAs (ncRNAs), such as microRNAs and long noncoding RNAs (lncRNAs), participate in cellula...
Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors worldwide. In view of t...
Hepatocellular carcinoma (HCC) is currently still a major factor leading to death, lacking of reliab...
Abstract Circular RNAs (circRNAs) are a large class of noncoding RNAs that have potential regulatory...
Circular RNAs (circRNAs), which are a class of endogenous RNA with covalently closed loops, play imp...
Mature microRNAs (miRNAs) are a class of small non-coding RNAs involved in posttranslational gene si...
Copyright © 2015 Jing Shen et al.This is an open access article distributed under the Creative Commo...
Abstract RNA methylation modification plays a crucial role as an epigenetic regulator in the oncogen...
Emerging evidence has shown that circular RNAs (circRNAs) and DNA methylation play important roles i...
Epidemiological data consistently rank hepatocellular carcinoma (HCC) as one of the leading causes o...
Abstract Circular RNAs (circRNAs), a novel type of non-coding RNAs (ncRNAs), have a covalently close...
Circular RNA (circRNA) can participate in various biological processes, including tumorigenesis, thr...
Pathologic alterations in epigenetic regulation have long been considered a hallmark of many cancers...
Background. Previous studies, including ours, have examined the regulation of microRNAs (miRNAs) by ...
Abstract At present, as hotspot members of the noncoding RNA network, circular RNAs (circRNAs) with ...
Noncoding RNAs (ncRNAs), such as microRNAs and long noncoding RNAs (lncRNAs), participate in cellula...
Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors worldwide. In view of t...
Hepatocellular carcinoma (HCC) is currently still a major factor leading to death, lacking of reliab...
Abstract Circular RNAs (circRNAs) are a large class of noncoding RNAs that have potential regulatory...
Circular RNAs (circRNAs), which are a class of endogenous RNA with covalently closed loops, play imp...
Mature microRNAs (miRNAs) are a class of small non-coding RNAs involved in posttranslational gene si...
Copyright © 2015 Jing Shen et al.This is an open access article distributed under the Creative Commo...
Abstract RNA methylation modification plays a crucial role as an epigenetic regulator in the oncogen...
Emerging evidence has shown that circular RNAs (circRNAs) and DNA methylation play important roles i...
Epidemiological data consistently rank hepatocellular carcinoma (HCC) as one of the leading causes o...
Abstract Circular RNAs (circRNAs), a novel type of non-coding RNAs (ncRNAs), have a covalently close...
Circular RNA (circRNA) can participate in various biological processes, including tumorigenesis, thr...
Pathologic alterations in epigenetic regulation have long been considered a hallmark of many cancers...