Network-meta analysis of 9 kinds of patent Chinese medicine for nourishing qi and activating blood in the treatment of angina pectoris of coronary heart disease

Objective: To evaluate the efficacy and safety of Yiqi Huoxue oral Chinese patent medicine in the treatment of angina pectoris. Methods: the databases of EMBASE, PubMed, CNKI, Wanfang and VIP were searched by computer, and the randomized controlled trial (RCT) of Yiqi Huoxue Chinese patent medicine in the treatment of angina pectoris of coronary heart disease (CHD) was searched until December 2019. By using stata15.1 software, the total clinical effective rate, the improvement rate of ECG, the improvement rate of angina pectoris, the attack frequency and duration of angina pectoris were taken as the outcome indicators for network meta analysis and mapping. Results: 51 RCTs were included, including 9 kinds of traditional Chinese medicine. The results of network meta analysis showed that: in terms of clinical total effective rate, the order was Shexiang Baoxin Pill(78.2%) > xueshuanxinming tablet > Dengzhan Shengmai capsule > Shengui Capsule > Tongxinluo capsule > Tongmai Yangxin pill > Yangxin tablet > Shexiang Tongxin drop pill > Naoxintong capsule; the improvement of ECG was Tongmai Yangxin pill (85.2%)> Yangxin tablet > Dengzhan Shengmai capsule > Shexiang Tongxin drop pill > Shexiang Baoxin Pill > Tongxinluo gum Capsule > Shengui Capsule > Naoxintong capsule; in order to reduce the frequency and duration of angina pectoris, they are conventional Naoxintong capsule(88.6%) > Shengui Capsule > Tongmai Yangxin pill > Shexiang Baoxin Pill > xueshuanxinmingpian > Tongxinluo capsule > Shexiang Tongxin drop pill > Dengzhan Shengmai capsule; Shexiang Baoxin Pill(66.9%) > Dengzhan Shengmai capsule > Shexiang Tongxin drop pill > Tongxinluo capsule > xueshuanxinmingning capsule Tablet > Tongmai Yangxin pill. Conclusion: Traditional Chinese medicine combined with western medicine has obvious advantages in the treatment of angina pectoris. Shexiang Baoxin Pill, Dengzhan Shengmai capsule and Tongmai Yangxin pill can be given priority