The impact of vitamin D deficiency and autoimmunity on chronic spontaneous urticaria severity

Background and Design: In this study, we investigated the role of vitamin D deficiency and autoimmunity in chronic spontaneous urticaria (CSU) etiopathogenesis and their impact on the disease severity. Materials and Methods: Sixty patients with CSU aged between 18 and 65 years were enrolled to the study. The control group comprised 40 healthy individuals who had no episodes of urticaria or any other chronic diseases. An autologous serum skin test (ASST) was performed in all patients. In addition, 25 hydroxyvitamin D, thyroid autoantibodies (TA), anti-nuclear antibody (ANA), and basophils were evaluated in all groups. Urticaria activity score-7 (UAS7) and dermatological quality of life index (DLQI) of all patients were examined. Results: Angioedema was more frequent and UAS7 was higher in ASST-positive patients than ASST-negative patients (p=0.035, p=0.018, respectively).