The hydrophobic Phe cluster of MmpL3.
- Chih-Chia Su (573213)
- Philip A. Klenotic (11269221)
- Meng Cui (29943)
- Meinan Lyu (11269224)
- Christopher E. Morgan (11269227)
- Edward W. Yu (9745721)
Publication date
August 2021
DOI Publisher
Public Library of Science (PLoS)Abstract
(a) MD simulations indicate the minimum distance between T6D and the Phe cluster as a function of time. (b) The locations of T6D (especially the hydrocarbon tail) and the Phe cluster (F134, F449, F452, and F455) at 0 ns. The T6D molecule is colored cyan. Residues F134, F449, F452, and F455 are colored green. The secondary structural elements of MmpL3 are colored orange. (c) The locations of T6D (especially the hydrocarbon tail) and the Phe cluster (F134, F449, F452, and F455) at 4,000 ns. The T6D molecule is colored cyan. Residues F134, F449, F452, and F455 are colored green. The secondary structural elements of MmpL3 are colored orange. MmpL3, mycobacterial membrane protein large 3; T6D, trehalose 6-decanoate. (TIF)</p
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