Blood perfusion recovery and capillary density in mice post hindlimb ischaemia surgery and treatment with iECs.

(a) Blood perfusion recovery in ischaemic hindlimbs of mice treated with neonatal-derived iECs (red), patient-derived iECs from Patient 1 (green), Patient 2 (blue), and Patient 3 (grey), compared to controls (EBM) (black). Data were analysed by two-way repeated measures ANOVA and are presented as mean ± SEM (n = 23 for control group, n = 9 for iEC groups, * p< 0.05, ** p< 0.01, *** p< 0.001 compared to control. Asterix colour denotes associated treatment group). (b) Capillary density (capillaries/myocytes) for gastrocnemius muscle tissue from ischaemic hindlimbs collected at 14 days post-surgery for groups treated with neonatal-derived iECs (red), and patient-derived iECs for Patient 1 (green), Patient 2 (blue), and Patient 3 (grey), and control (EBM) (black). Data were analysed by one-way ANOVA with Bonferroni post hoc comparisons and are presented as mean ± SEM (n = 5–10 per group, * p< 0.05 compared to control).