Additional file 13 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits.

Hautbergue, Guillaume M
Castelli, Lydia M
Ferraiuolo, Laura
Sanchez-Martinez, Alvaro
Cooper-Knock, Johnathan
Higginbottom, Adrian
Lin, Ya-Hui
Bauer, Claudia S
Dodd, Jennifer E
Myszczynska, Monika A
Alam, Sarah M
Garneret, Pierre
Chandran, Jayanth S
Karyka, Evangelia
Stopford, Matthew J
Smith, Emma F
Kirby, Janine
Meyer, Kathrin
Kaspar, Brian K
Isaacs, Adrian M
El-Khamisy, Sherif F
De Vos, Kurt J
Ning, Ke
Azzouz, Mimoun
Whitworth, Alex
Shaw, Pamela J

July 2017

Hexanucleotide repeat expansions in the C9ORF72 gene are the commonest known genetic cause of amyotr...

Additional file 22 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Lydia M. Castelli (11257815)
Luisa Cutillo (265626)
Cleide Dos Santos Souza (11257818)
Alvaro Sanchez-Martinez (139273)
Ilaria Granata (1906462)
Ya-Hui Lin (458477)
Monika A. Myszczynska (11257821)
Paul R. Heath (9949426)
Matthew R. Livesey (8998676)
Ke Ning (6167282)
Mimoun Azzouz (345877)
Pamela J. Shaw (9267460)
Mario R. Guarracino (3274500)
Alexander J. Whitworth (9547347)
Laura Ferraiuolo (251300)
Marta Milo (232638)
Guillaume M. Hautbergue (11257824)

August 2021

Additional file 22 : Supplementary Figure 8. Characterisation of neural precursors cells (NPCs) deri...

SRSF1-dependent inhibition of C9ORF72 -repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Castelli, Lydia M.
Cutillo, Luisa
Souza, Cleide Dos Santos
Sanchez-Martinez, Alvaro
Granata, Ilaria
Lin, Ya-Hui
Myszczynska, Monika A.
Heath, Paul R.
Livesey, Matthew R.
Ning, Ke
Azzouz, Mimoun
Shaw, Pamela J.
Guarracino, Mario R.
Whitworth, Alexander J.
Ferraiuolo, Laura
Milo, Marta
Hautbergue, Guillaume M.

August 2021

Funder: Academy of Medical Sciences Springboard AwardAbstract: Background: Loss of motor neurons in ...

Additional file 6 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Lydia M. Castelli (11257815)
Luisa Cutillo (265626)
Cleide Dos Santos Souza (11257818)
Alvaro Sanchez-Martinez (139273)
Ilaria Granata (1906462)
Ya-Hui Lin (458477)
Monika A. Myszczynska (11257821)
Paul R. Heath (9949426)
Matthew R. Livesey (8998676)
Ke Ning (6167282)
Mimoun Azzouz (345877)
Pamela J. Shaw (9267460)
Mario R. Guarracino (3274500)
Alexander J. Whitworth (9547347)
Laura Ferraiuolo (251300)
Marta Milo (232638)
Guillaume M. Hautbergue (11257824)

August 2021

Additional file 6 : Table S5. Differentially-expressed transcripts in patient-derived neurons

Additional file 11 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Lydia M. Castelli (11257815)
Luisa Cutillo (265626)
Cleide Dos Santos Souza (11257818)
Alvaro Sanchez-Martinez (139273)
Ilaria Granata (1906462)
Ya-Hui Lin (458477)
Monika A. Myszczynska (11257821)
Paul R. Heath (9949426)
Matthew R. Livesey (8998676)
Ke Ning (6167282)
Mimoun Azzouz (345877)
Pamela J. Shaw (9267460)
Mario R. Guarracino (3274500)
Alexander J. Whitworth (9547347)
Laura Ferraiuolo (251300)
Marta Milo (232638)
Guillaume M. Hautbergue (11257824)

August 2021

Additional file 11 : Table S9. mRNA nuclear export analysis in patient-derived neurons

Additional file 12 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Lydia M. Castelli (11257815)
Luisa Cutillo (265626)
Cleide Dos Santos Souza (11257818)
Alvaro Sanchez-Martinez (139273)
Ilaria Granata (1906462)
Ya-Hui Lin (458477)
Monika A. Myszczynska (11257821)
Paul R. Heath (9949426)
Matthew R. Livesey (8998676)
Ke Ning (6167282)
Mimoun Azzouz (345877)
Pamela J. Shaw (9267460)
Mario R. Guarracino (3274500)
Alexander J. Whitworth (9547347)
Laura Ferraiuolo (251300)
Marta Milo (232638)
Guillaume M. Hautbergue (11257824)

August 2021

Additional file 12 : Supplementary Figure 2. Enlargement of Fig. 3b. mRNA nuclear export analysis up...

Additional file 17 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Lydia M. Castelli (11257815)
Luisa Cutillo (265626)
Cleide Dos Santos Souza (11257818)
Alvaro Sanchez-Martinez (139273)
Ilaria Granata (1906462)
Ya-Hui Lin (458477)
Monika A. Myszczynska (11257821)
Paul R. Heath (9949426)
Matthew R. Livesey (8998676)
Ke Ning (6167282)
Mimoun Azzouz (345877)
Pamela J. Shaw (9267460)
Mario R. Guarracino (3274500)
Alexander J. Whitworth (9547347)
Laura Ferraiuolo (251300)
Marta Milo (232638)
Guillaume M. Hautbergue (11257824)

August 2021

Additional file 17 : Table S12. C9ORF72-ALS disease-modifying gene expression signature

Additional file 16 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Lydia M. Castelli (11257815)
Luisa Cutillo (265626)
Cleide Dos Santos Souza (11257818)
Alvaro Sanchez-Martinez (139273)
Ilaria Granata (1906462)
Ya-Hui Lin (458477)
Monika A. Myszczynska (11257821)
Paul R. Heath (9949426)
Matthew R. Livesey (8998676)
Ke Ning (6167282)
Mimoun Azzouz (345877)
Pamela J. Shaw (9267460)
Mario R. Guarracino (3274500)
Alexander J. Whitworth (9547347)
Laura Ferraiuolo (251300)
Marta Milo (232638)
Guillaume M. Hautbergue (11257824)

August 2021

Additional file 16 : Supplementary Figure 4. Enlargement of Fig. 5b. C9-ALS disease-modifying signat...

Additional file 8 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Lydia M. Castelli (11257815)
Luisa Cutillo (265626)
Cleide Dos Santos Souza (11257818)
Alvaro Sanchez-Martinez (139273)
Ilaria Granata (1906462)
Ya-Hui Lin (458477)
Monika A. Myszczynska (11257821)
Paul R. Heath (9949426)
Matthew R. Livesey (8998676)
Ke Ning (6167282)
Mimoun Azzouz (345877)
Pamela J. Shaw (9267460)
Mario R. Guarracino (3274500)
Alexander J. Whitworth (9547347)
Laura Ferraiuolo (251300)
Marta Milo (232638)
Guillaume M. Hautbergue (11257824)

August 2021

Additional file 8 : Supplementary Figure 1. Downregulation of mitosis/ cell proliferation/ cancer ma...

Additional file 23 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Lydia M. Castelli (11257815)
Luisa Cutillo (265626)
Cleide Dos Santos Souza (11257818)
Alvaro Sanchez-Martinez (139273)
Ilaria Granata (1906462)
Ya-Hui Lin (458477)
Monika A. Myszczynska (11257821)
Paul R. Heath (9949426)
Matthew R. Livesey (8998676)
Ke Ning (6167282)
Mimoun Azzouz (345877)
Pamela J. Shaw (9267460)
Mario R. Guarracino (3274500)
Alexander J. Whitworth (9547347)
Laura Ferraiuolo (251300)
Marta Milo (232638)
Guillaume M. Hautbergue (11257824)

August 2021

Additional file 23 : Supplementary Figure 9. Differentiation of iPSCs from healthy and C9ORF72-ALS p...

SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis.

Castelli, Lydia M
Cutillo, Luisa
Souza, Cleide Dos Santos
Sanchez-Martinez, Alvaro
Granata, Ilaria
Lin, Ya-Hui
Myszczynska, Monika A
Heath, Paul R
Livesey, Matthew R
Ning, Ke
Azzouz, Mimoun
Shaw, Pamela J
Guarracino, Mario R
Whitworth, Alexander J
Ferraiuolo, Laura
Milo, Marta
Hautbergue, Guillaume M

September 2021

BackgroundLoss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysi...

SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Lydia M. Castelli
Luisa Cutillo
Cleide Dos Santos Souza
Alvaro Sanchez-Martinez
Ilaria Granata
Ya-Hui Lin
Monika A. Myszczynska
Paul R. Heath
Matthew R. Livesey
Ke Ning
Mimoun Azzouz
Pamela J. Shaw
Mario R. Guarracino
Alexander J. Whitworth
Laura Ferraiuolo
Marta Milo
Guillaume M. Hautbergue

August 2021

Abstract Background Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressiv...

Additional file 21 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Lydia M. Castelli (11257815)
Luisa Cutillo (265626)
Cleide Dos Santos Souza (11257818)
Alvaro Sanchez-Martinez (139273)
Ilaria Granata (1906462)
Ya-Hui Lin (458477)
Monika A. Myszczynska (11257821)
Paul R. Heath (9949426)
Matthew R. Livesey (8998676)
Ke Ning (6167282)
Mimoun Azzouz (345877)
Pamela J. Shaw (9267460)
Mario R. Guarracino (3274500)
Alexander J. Whitworth (9547347)
Laura Ferraiuolo (251300)
Marta Milo (232638)
Guillaume M. Hautbergue (11257824)

August 2021

Additional file 21 : Supplementary Figure 7. Quantification of KCNN1-4 mRNA expression levels in hea...

SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits

Whitworth, Alex
Sanchez-Martinez, Alvaro
Alam, Sarah M

July 2017

Hexanucleotide repeat expansions in the C9ORF72 gene are the commonest known genetic cause of amyotr...

Additional file 20 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Lydia M. Castelli (11257815)
Luisa Cutillo (265626)
Cleide Dos Santos Souza (11257818)
Alvaro Sanchez-Martinez (139273)
Ilaria Granata (1906462)
Ya-Hui Lin (458477)
Monika A. Myszczynska (11257821)
Paul R. Heath (9949426)
Matthew R. Livesey (8998676)
Ke Ning (6167282)
Mimoun Azzouz (345877)
Pamela J. Shaw (9267460)
Mario R. Guarracino (3274500)
Alexander J. Whitworth (9547347)
Laura Ferraiuolo (251300)
Marta Milo (232638)
Guillaume M. Hautbergue (11257824)

August 2021

Additional file 20 : Supplementary Figure 6. Orthologous genes in the human and fly genomes. BioMart...

SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits.

Hautbergue, Guillaume M
Castelli, Lydia M
Ferraiuolo, Laura
Sanchez-Martinez, Alvaro
Cooper-Knock, Johnathan
Higginbottom, Adrian
Lin, Ya-Hui
Bauer, Claudia S
Dodd, Jennifer E
Myszczynska, Monika A
Alam, Sarah M
Garneret, Pierre
Chandran, Jayanth S
Karyka, Evangelia
Stopford, Matthew J
Smith, Emma F
Kirby, Janine
Meyer, Kathrin
Kaspar, Brian K
Isaacs, Adrian M
El-Khamisy, Sherif F
De Vos, Kurt J
Ning, Ke
Azzouz, Mimoun
Whitworth, Alex
Shaw, Pamela J

July 2017

Hexanucleotide repeat expansions in the C9ORF72 gene are the commonest known genetic cause of amyotr...

Additional file 22 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Lydia M. Castelli (11257815)
Luisa Cutillo (265626)
Cleide Dos Santos Souza (11257818)
Alvaro Sanchez-Martinez (139273)
Ilaria Granata (1906462)
Ya-Hui Lin (458477)
Monika A. Myszczynska (11257821)
Paul R. Heath (9949426)
Matthew R. Livesey (8998676)
Ke Ning (6167282)
Mimoun Azzouz (345877)
Pamela J. Shaw (9267460)
Mario R. Guarracino (3274500)
Alexander J. Whitworth (9547347)
Laura Ferraiuolo (251300)
Marta Milo (232638)
Guillaume M. Hautbergue (11257824)

August 2021

Additional file 22 : Supplementary Figure 8. Characterisation of neural precursors cells (NPCs) deri...

SRSF1-dependent inhibition of C9ORF72 -repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Castelli, Lydia M.
Cutillo, Luisa
Souza, Cleide Dos Santos
Sanchez-Martinez, Alvaro
Granata, Ilaria
Lin, Ya-Hui
Myszczynska, Monika A.
Heath, Paul R.
Livesey, Matthew R.
Ning, Ke
Azzouz, Mimoun
Shaw, Pamela J.
Guarracino, Mario R.
Whitworth, Alexander J.
Ferraiuolo, Laura
Milo, Marta
Hautbergue, Guillaume M.

August 2021

Funder: Academy of Medical Sciences Springboard AwardAbstract: Background: Loss of motor neurons in ...

Additional file 6 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Lydia M. Castelli (11257815)
Luisa Cutillo (265626)
Cleide Dos Santos Souza (11257818)
Alvaro Sanchez-Martinez (139273)
Ilaria Granata (1906462)
Ya-Hui Lin (458477)
Monika A. Myszczynska (11257821)
Paul R. Heath (9949426)
Matthew R. Livesey (8998676)
Ke Ning (6167282)
Mimoun Azzouz (345877)
Pamela J. Shaw (9267460)
Mario R. Guarracino (3274500)
Alexander J. Whitworth (9547347)
Laura Ferraiuolo (251300)
Marta Milo (232638)
Guillaume M. Hautbergue (11257824)

August 2021

Additional file 6 : Table S5. Differentially-expressed transcripts in patient-derived neurons

Additional file 11 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Lydia M. Castelli (11257815)
Luisa Cutillo (265626)
Cleide Dos Santos Souza (11257818)
Alvaro Sanchez-Martinez (139273)
Ilaria Granata (1906462)
Ya-Hui Lin (458477)
Monika A. Myszczynska (11257821)
Paul R. Heath (9949426)
Matthew R. Livesey (8998676)
Ke Ning (6167282)
Mimoun Azzouz (345877)
Pamela J. Shaw (9267460)
Mario R. Guarracino (3274500)
Alexander J. Whitworth (9547347)
Laura Ferraiuolo (251300)
Marta Milo (232638)
Guillaume M. Hautbergue (11257824)

August 2021

Additional file 11 : Table S9. mRNA nuclear export analysis in patient-derived neurons

Additional file 12 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Lydia M. Castelli (11257815)
Luisa Cutillo (265626)
Cleide Dos Santos Souza (11257818)
Alvaro Sanchez-Martinez (139273)
Ilaria Granata (1906462)
Ya-Hui Lin (458477)
Monika A. Myszczynska (11257821)
Paul R. Heath (9949426)
Matthew R. Livesey (8998676)
Ke Ning (6167282)
Mimoun Azzouz (345877)
Pamela J. Shaw (9267460)
Mario R. Guarracino (3274500)
Alexander J. Whitworth (9547347)
Laura Ferraiuolo (251300)
Marta Milo (232638)
Guillaume M. Hautbergue (11257824)

August 2021

Additional file 12 : Supplementary Figure 2. Enlargement of Fig. 3b. mRNA nuclear export analysis up...

Additional file 17 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Lydia M. Castelli (11257815)
Luisa Cutillo (265626)
Cleide Dos Santos Souza (11257818)
Alvaro Sanchez-Martinez (139273)
Ilaria Granata (1906462)
Ya-Hui Lin (458477)
Monika A. Myszczynska (11257821)
Paul R. Heath (9949426)
Matthew R. Livesey (8998676)
Ke Ning (6167282)
Mimoun Azzouz (345877)
Pamela J. Shaw (9267460)
Mario R. Guarracino (3274500)
Alexander J. Whitworth (9547347)
Laura Ferraiuolo (251300)
Marta Milo (232638)
Guillaume M. Hautbergue (11257824)

August 2021

Additional file 17 : Table S12. C9ORF72-ALS disease-modifying gene expression signature

Additional file 16 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Lydia M. Castelli (11257815)
Luisa Cutillo (265626)
Cleide Dos Santos Souza (11257818)
Alvaro Sanchez-Martinez (139273)
Ilaria Granata (1906462)
Ya-Hui Lin (458477)
Monika A. Myszczynska (11257821)
Paul R. Heath (9949426)
Matthew R. Livesey (8998676)
Ke Ning (6167282)
Mimoun Azzouz (345877)
Pamela J. Shaw (9267460)
Mario R. Guarracino (3274500)
Alexander J. Whitworth (9547347)
Laura Ferraiuolo (251300)
Marta Milo (232638)
Guillaume M. Hautbergue (11257824)

August 2021

Additional file 16 : Supplementary Figure 4. Enlargement of Fig. 5b. C9-ALS disease-modifying signat...

Additional file 8 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Lydia M. Castelli (11257815)
Luisa Cutillo (265626)
Cleide Dos Santos Souza (11257818)
Alvaro Sanchez-Martinez (139273)
Ilaria Granata (1906462)
Ya-Hui Lin (458477)
Monika A. Myszczynska (11257821)
Paul R. Heath (9949426)
Matthew R. Livesey (8998676)
Ke Ning (6167282)
Mimoun Azzouz (345877)
Pamela J. Shaw (9267460)
Mario R. Guarracino (3274500)
Alexander J. Whitworth (9547347)
Laura Ferraiuolo (251300)
Marta Milo (232638)
Guillaume M. Hautbergue (11257824)

August 2021

Additional file 8 : Supplementary Figure 1. Downregulation of mitosis/ cell proliferation/ cancer ma...

Additional file 23 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Lydia M. Castelli (11257815)
Luisa Cutillo (265626)
Cleide Dos Santos Souza (11257818)
Alvaro Sanchez-Martinez (139273)
Ilaria Granata (1906462)
Ya-Hui Lin (458477)
Monika A. Myszczynska (11257821)
Paul R. Heath (9949426)
Matthew R. Livesey (8998676)
Ke Ning (6167282)
Mimoun Azzouz (345877)
Pamela J. Shaw (9267460)
Mario R. Guarracino (3274500)
Alexander J. Whitworth (9547347)
Laura Ferraiuolo (251300)
Marta Milo (232638)
Guillaume M. Hautbergue (11257824)

August 2021

Additional file 23 : Supplementary Figure 9. Differentiation of iPSCs from healthy and C9ORF72-ALS p...

SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis.

Castelli, Lydia M
Cutillo, Luisa
Souza, Cleide Dos Santos
Sanchez-Martinez, Alvaro
Granata, Ilaria
Lin, Ya-Hui
Myszczynska, Monika A
Heath, Paul R
Livesey, Matthew R
Ning, Ke
Azzouz, Mimoun
Shaw, Pamela J
Guarracino, Mario R
Whitworth, Alexander J
Ferraiuolo, Laura
Milo, Marta
Hautbergue, Guillaume M

September 2021

BackgroundLoss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysi...

SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Lydia M. Castelli
Luisa Cutillo
Cleide Dos Santos Souza
Alvaro Sanchez-Martinez
Ilaria Granata
Ya-Hui Lin
Monika A. Myszczynska
Paul R. Heath
Matthew R. Livesey
Ke Ning
Mimoun Azzouz
Pamela J. Shaw
Mario R. Guarracino
Alexander J. Whitworth
Laura Ferraiuolo
Marta Milo
Guillaume M. Hautbergue

August 2021

Abstract Background Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressiv...

Additional file 21 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Lydia M. Castelli (11257815)
Luisa Cutillo (265626)
Cleide Dos Santos Souza (11257818)
Alvaro Sanchez-Martinez (139273)
Ilaria Granata (1906462)
Ya-Hui Lin (458477)
Monika A. Myszczynska (11257821)
Paul R. Heath (9949426)
Matthew R. Livesey (8998676)
Ke Ning (6167282)
Mimoun Azzouz (345877)
Pamela J. Shaw (9267460)
Mario R. Guarracino (3274500)
Alexander J. Whitworth (9547347)
Laura Ferraiuolo (251300)
Marta Milo (232638)
Guillaume M. Hautbergue (11257824)

August 2021

Additional file 21 : Supplementary Figure 7. Quantification of KCNN1-4 mRNA expression levels in hea...

SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits

Whitworth, Alex
Sanchez-Martinez, Alvaro
Alam, Sarah M

July 2017

Hexanucleotide repeat expansions in the C9ORF72 gene are the commonest known genetic cause of amyotr...

Additional file 20 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Lydia M. Castelli (11257815)
Luisa Cutillo (265626)
Cleide Dos Santos Souza (11257818)
Alvaro Sanchez-Martinez (139273)
Ilaria Granata (1906462)
Ya-Hui Lin (458477)
Monika A. Myszczynska (11257821)
Paul R. Heath (9949426)
Matthew R. Livesey (8998676)
Ke Ning (6167282)
Mimoun Azzouz (345877)
Pamela J. Shaw (9267460)
Mario R. Guarracino (3274500)
Alexander J. Whitworth (9547347)
Laura Ferraiuolo (251300)
Marta Milo (232638)
Guillaume M. Hautbergue (11257824)

August 2021

Additional file 20 : Supplementary Figure 6. Orthologous genes in the human and fly genomes. BioMart...

SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits.

Hautbergue, Guillaume M
Castelli, Lydia M
Ferraiuolo, Laura
Sanchez-Martinez, Alvaro
Cooper-Knock, Johnathan
Higginbottom, Adrian
Lin, Ya-Hui
Bauer, Claudia S
Dodd, Jennifer E
Myszczynska, Monika A
Alam, Sarah M
Garneret, Pierre
Chandran, Jayanth S
Karyka, Evangelia
Stopford, Matthew J
Smith, Emma F
Kirby, Janine
Meyer, Kathrin
Kaspar, Brian K
Isaacs, Adrian M
El-Khamisy, Sherif F
De Vos, Kurt J
Ning, Ke
Azzouz, Mimoun
Whitworth, Alex
Shaw, Pamela J

July 2017

Hexanucleotide repeat expansions in the C9ORF72 gene are the commonest known genetic cause of amyotr...

Additional file 22 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Lydia M. Castelli (11257815)
Luisa Cutillo (265626)
Cleide Dos Santos Souza (11257818)
Alvaro Sanchez-Martinez (139273)
Ilaria Granata (1906462)
Ya-Hui Lin (458477)
Monika A. Myszczynska (11257821)
Paul R. Heath (9949426)
Matthew R. Livesey (8998676)
Ke Ning (6167282)
Mimoun Azzouz (345877)
Pamela J. Shaw (9267460)
Mario R. Guarracino (3274500)
Alexander J. Whitworth (9547347)
Laura Ferraiuolo (251300)
Marta Milo (232638)
Guillaume M. Hautbergue (11257824)

August 2021

Additional file 22 : Supplementary Figure 8. Characterisation of neural precursors cells (NPCs) deri...

SRSF1-dependent inhibition of C9ORF72 -repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Castelli, Lydia M.
Cutillo, Luisa
Souza, Cleide Dos Santos
Sanchez-Martinez, Alvaro
Granata, Ilaria
Lin, Ya-Hui
Myszczynska, Monika A.
Heath, Paul R.
Livesey, Matthew R.
Ning, Ke
Azzouz, Mimoun
Shaw, Pamela J.
Guarracino, Mario R.
Whitworth, Alexander J.
Ferraiuolo, Laura
Milo, Marta
Hautbergue, Guillaume M.

August 2021

Funder: Academy of Medical Sciences Springboard AwardAbstract: Background: Loss of motor neurons in ...

Additional file 13 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Abstract

Extracted data

Additional file 13 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Abstract

Extracted data

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