Additional file 20 : Supplementary Figure 6. Orthologous genes in the human and fly genomes. BioMart ( http://www.ensembl.org/biomart/martview ) Ensembl Genes 99 was used with the Homo sapiens GRCh38.p13 and the Drosophila melanogaster BDGP6.28 genomes. A multispecies comparison was performed on 25.04.2020 based on (i) Homologue filters, Orthologous genes only or (ii) Homologue filters, Orthologous human Genes only. (A) 3681 human coding genes out of 20,449 have conserved fly orthologous genes. (B) 3411 fly coding genes of 13,947 have conserved human orthologous genes. List of orthologous genes are available upon request
Figure S1. A computational pipeline to identify putative regulatory SNPs. The human, mouse, and chic...
Supplementary Tables. Table S1. The 26 RNAi knockdown phenotypes surveyed in this study. We identify...
Abstract Background Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressiv...
Additional file 12 : Supplementary Figure 2. Enlargement of Fig. 3b. mRNA nuclear export analysis up...
Additional file 23 : Supplementary Figure 9. Differentiation of iPSCs from healthy and C9ORF72-ALS p...
Additional file 6 : Table S5. Differentially-expressed transcripts in patient-derived neurons
Additional file 13 : Table S10. Differentially-expressed transcripts in Drosophil
Additional file 16 : Supplementary Figure 4. Enlargement of Fig. 5b. C9-ALS disease-modifying signat...
Additional file 11 : Table S9. mRNA nuclear export analysis in patient-derived neurons
Additional file 8 : Supplementary Figure 1. Downregulation of mitosis/ cell proliferation/ cancer ma...
Additional file 17 : Table S12. C9ORF72-ALS disease-modifying gene expression signature
List of all significant differentially expressed genes. FBgn: Flybase symbol; Symbol _mel: symbol of...
Additional file 22 : Supplementary Figure 8. Characterisation of neural precursors cells (NPCs) deri...
Additional file 21 : Supplementary Figure 7. Quantification of KCNN1-4 mRNA expression levels in hea...
BACKGROUND: Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paraly...
Figure S1. A computational pipeline to identify putative regulatory SNPs. The human, mouse, and chic...
Supplementary Tables. Table S1. The 26 RNAi knockdown phenotypes surveyed in this study. We identify...
Abstract Background Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressiv...
Additional file 12 : Supplementary Figure 2. Enlargement of Fig. 3b. mRNA nuclear export analysis up...
Additional file 23 : Supplementary Figure 9. Differentiation of iPSCs from healthy and C9ORF72-ALS p...
Additional file 6 : Table S5. Differentially-expressed transcripts in patient-derived neurons
Additional file 13 : Table S10. Differentially-expressed transcripts in Drosophil
Additional file 16 : Supplementary Figure 4. Enlargement of Fig. 5b. C9-ALS disease-modifying signat...
Additional file 11 : Table S9. mRNA nuclear export analysis in patient-derived neurons
Additional file 8 : Supplementary Figure 1. Downregulation of mitosis/ cell proliferation/ cancer ma...
Additional file 17 : Table S12. C9ORF72-ALS disease-modifying gene expression signature
List of all significant differentially expressed genes. FBgn: Flybase symbol; Symbol _mel: symbol of...
Additional file 22 : Supplementary Figure 8. Characterisation of neural precursors cells (NPCs) deri...
Additional file 21 : Supplementary Figure 7. Quantification of KCNN1-4 mRNA expression levels in hea...
BACKGROUND: Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paraly...
Figure S1. A computational pipeline to identify putative regulatory SNPs. The human, mouse, and chic...
Supplementary Tables. Table S1. The 26 RNAi knockdown phenotypes surveyed in this study. We identify...
Abstract Background Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressiv...