Additional file 23 : Supplementary Figure 9. Differentiation of iPSCs from healthy and C9ORF72-ALS patients into functional motor neurons. (A) Schematic representation of the motor neuron differentiation protocol. (B) Representative images of motor neurons stained for the neuronal markers Tuj1, SMI-32, NeuN, MAP2 and the motor neuron specific marker ChAT. Scale bars: 50 μm
The C9orf72 hexanucleotide repeat expansion [GGGGCC]n is the most common cause of familial amyotroph...
Levels of endogenous versus overexpressed C9orf72 in N2a and HEK293T cells. N2a (a) and HEK293T (b) ...
Funder: Academy of Medical Sciences Springboard AwardAbstract: Background: Loss of motor neurons in ...
Additional file 22 : Supplementary Figure 8. Characterisation of neural precursors cells (NPCs) deri...
Additional file 8 : Supplementary Figure 1. Downregulation of mitosis/ cell proliferation/ cancer ma...
Additional file 16 : Supplementary Figure 4. Enlargement of Fig. 5b. C9-ALS disease-modifying signat...
Additional file 11 : Table S9. mRNA nuclear export analysis in patient-derived neurons
Additional file 6 : Table S5. Differentially-expressed transcripts in patient-derived neurons
Additional file 17 : Table S12. C9ORF72-ALS disease-modifying gene expression signature
Additional file 12 : Supplementary Figure 2. Enlargement of Fig. 3b. mRNA nuclear export analysis up...
Additional file 21 : Supplementary Figure 7. Quantification of KCNN1-4 mRNA expression levels in hea...
Additional file 13 : Table S10. Differentially-expressed transcripts in Drosophil
Additional file 20 : Supplementary Figure 6. Orthologous genes in the human and fly genomes. BioMart...
BackgroundLoss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysi...
Abstract Background Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressiv...
The C9orf72 hexanucleotide repeat expansion [GGGGCC]n is the most common cause of familial amyotroph...
Levels of endogenous versus overexpressed C9orf72 in N2a and HEK293T cells. N2a (a) and HEK293T (b) ...
Funder: Academy of Medical Sciences Springboard AwardAbstract: Background: Loss of motor neurons in ...
Additional file 22 : Supplementary Figure 8. Characterisation of neural precursors cells (NPCs) deri...
Additional file 8 : Supplementary Figure 1. Downregulation of mitosis/ cell proliferation/ cancer ma...
Additional file 16 : Supplementary Figure 4. Enlargement of Fig. 5b. C9-ALS disease-modifying signat...
Additional file 11 : Table S9. mRNA nuclear export analysis in patient-derived neurons
Additional file 6 : Table S5. Differentially-expressed transcripts in patient-derived neurons
Additional file 17 : Table S12. C9ORF72-ALS disease-modifying gene expression signature
Additional file 12 : Supplementary Figure 2. Enlargement of Fig. 3b. mRNA nuclear export analysis up...
Additional file 21 : Supplementary Figure 7. Quantification of KCNN1-4 mRNA expression levels in hea...
Additional file 13 : Table S10. Differentially-expressed transcripts in Drosophil
Additional file 20 : Supplementary Figure 6. Orthologous genes in the human and fly genomes. BioMart...
BackgroundLoss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysi...
Abstract Background Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressiv...
The C9orf72 hexanucleotide repeat expansion [GGGGCC]n is the most common cause of familial amyotroph...
Levels of endogenous versus overexpressed C9orf72 in N2a and HEK293T cells. N2a (a) and HEK293T (b) ...
Funder: Academy of Medical Sciences Springboard AwardAbstract: Background: Loss of motor neurons in ...