Intersection of homologous aging-correlated genes.

A) Sample regression analysis of the overlapping 50 aging correlated genes across humans. B) Histogram of R2 values of human age prediction using the conserved 50 aging correlated genes with a mean R2 of 0.46. C) Sample regression analysis of the mean R2 values predicting Drosophila age using the 50 aging correlated genes. D) Histogram of R2 values predicting Drosophila age using the conserved 50 aging correlated genes with a mean R2 of 0.85. All results calculated using XGBoost. All histogram results represent averages across 1000 bootstrapped random samplings where the regressor or classifier was trained on 75% of the samples and tested on 25%. All histogram values are reported as the mean across 1000 iterations. Median AE stands for Median Average Error.