Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2
- Thomas Barthlott
- Adam E. Handel
- Hong Ying Teh
- Rushika C. Wirasinha
- Katrin Hafen
- Saulius Žuklys
- Benoit Roch
- Stuart H. Orkin
- Jean-Pierre de Villartay
- Stephen R. Daley
- Georg A. Holländer
Publication date
June 2021
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
Development of the T cells requires functions from thymic epithelial cells, whose development and function are epigenetically regulated. Here the authors show that inactivation of the polycomb repressive complex 2 (PRC2) alters the H3K27me3 configuration, reduces TEC functions, reveals a specific TEC subset, and hampers T cell development
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