Investigating the Protective Effects of Endurance and Resistance Trainings on Serum level of Cellular and Vascular Adhesive Molecules in Obese Men

Background and objectives: The aim of this study was to compare the effect of an eight-weeks endurance and strength training on levels of cellular and vascular adhesion molecules in obese men. Methods: Twenty-four obese volunteer men as subjects in this study were selected from Tehran and randomly assigned to control, endurance training, and strength training groups. The enduranBackground and objectives: Obesity, particularly abdominal obesity, is the most common cause of metabolic abnormalities, such as metabolic syndrome. The aim of this study was to compare effects of eight weeks of endurance and strength trainings on serum levels of cellular and vascular adhesion molecules in obese men. Methods: Twenty-four obese men were randomly assigned to control, endurance training and strength training groups. The endurance training group performed a modified treadmill running protocol with an intensity of 50-70% of maximum heart rate. The resistance training included chest press, armpit stretch and leg and crus presses at intensity of 50-80% of one-repetition maximum. Serum levels of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion protein 1 (VCAM--1) were measured using commercial ELISA kits. Data were analyzed by one-way ANOVA and post hoc Tukey test at significance of 0.05. Results: Serum VCAM-1 and ICAM-1 levels decreased significantly in both training groups compared to the control group (P=0.0001). The reduction of serum VCAM-1 and ICAM-1 levels was more significant in the endurance training group than in the resistance training group. Conclusion: Given the favorable effects of endurance and resistance trainings on serum levels of VCAM-1 and ICAM-1, the eight-week training could be performed as a protective intervention in obese people.ce training group performed a modified running protocol with an exercise intensity of 50% to 70% of HRmax on the treadmill. Resistance exercises also included chest press, armpit stretch, and leg and crus presses. The training intensity was 50% to 80% of 1-RM. Serum levels of VCAM-1 and ICAM-1 were measured using ELISA commercial kits. Data were analyzed by One-way ANOVA and post hoc Tukey at the significant level P