Health-Related Quality of Life and Productivity Among US Patients with Severe Asthma

Weily Soong,1 Bradley E Chipps,2 Sean O’Quinn,3 Jennifer Trevor,4 Warner W Carr,5 Laura Belton,6 Frank Trudo,7 Christopher S Ambrose3 1Alabama Allergy & Asthma Center, Birmingham, AL, USA; 2Capital Allergy & Respiratory Disease Center, Sacramento, CA, USA; 3BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD, USA; 4University of Alabama at Birmingham, Birmingham, AL, USA; 5Allergy & Asthma Associates of Southern California, Mission Viejo, CA, USA; 6Biostatistics, AstraZeneca, Cambridge, UK; 7BioPharmaceuticals Medical, AstraZeneca, Wilmington, DE, USACorrespondence: Weily SoongAlabama Allergy & Asthma Center, 504 Brookwood Boulevard, Birmingham, AL, 35209, USATel +1 205 871-9661Fax +1 205 870-1621Email wsoong@alabamaallergy.comBackground: Health-related quality of life (HRQoL) and productivity of patients with confirmed severe asthma (SA) have not been well characterized in large, real-world populations.Purpose: To characterize SA impact on HRQoL, work productivity, and activity impairment in a large, real-world cohort in the United States (US).Methods: CHRONICLE is an observational study of specialist-treated adults (≥ 18 years) in the US with SA receiving biologics or maintenance systemic corticosteroids (mSCS), or those persistently uncontrolled by high-dosage inhaled corticosteroids with additional controllers (HD ICS+). At enrollment, patients completed the St. George’s Respiratory Questionnaire (SGRQ) and Work Productivity and Activity Impairment (WPAI) questionnaire. Results were analyzed for those enrolled between February 2018 and February 2020.Results: Among patients who completed enrollment questionnaires (n = 1109), mean age was 54 years and most were women (70%). Among SGRQ respondents (n = 960), mean (SD) total score was 43 (23); 51% reported good/very good health. Among WPAI respondents (n = 1057; 566 employed), mean (SD) overall work impairment was 21% (25). Patients receiving biologics (vs mSCS, HD ICS+ only) had better SGRQ total scores (38 vs 59, 48) and lower work impairment (17% vs 34%, 27%). Patients with better SGRQ activity scores relative to symptom scores had better SGRQ impacts scores, total scores, and reported better overall health.Conclusion: SA significantly affects HRQoL, work productivity, and activity. The SGRQ is a valuable research instrument for evaluating HRQoL in SA. Due to its association with HRQoL and overall health, activity impairment should be a focus when monitoring patients’ disease control.Study Registration: ClinicalTrials.gov Identifier: NCT03373045.Keywords: real-world, St. George’s Respiratory Questionnaire, SGRQ, WPAI, symptoms, activit