International audienceThe Vuache fault is a prominent structure cutting the southernmost Swiss Molasse basin, from the Subalpine massifs to the Jura range. It controls a superficial (0 to 3 km), moderate (moment magnitude 5) and recurrent (a few events per century) seismicity. In order to address the seismic hazard associated to this fault, we compiled existing data, performed new field investigations and reprocessed existing seismic lines. The newly acquired data validate the hypothesis of an active structure. Its imprint in the landscape and its Quaternary long-term activity are demonstrated, especially by the offset of incised small valleys. Some sites also reveal the occurrence of Quaternary deposits deformed along the fault. Despite th...