The aim of this PhD Thesis was to build and develop a stochastic calculus (in particular a stochastic integral) with respect to multifractional Brownian motion (mBm). Since the choice of the theory and the tools to use was not fixed a priori, we chose the White Noise theory which generalizes, in the case of fractional Brownian motion (fBm) , the Malliavin calculus. The first chapter of this thesis presents several notions we will use in the sequel.In the second chapter we present a construction as well as the main properties of stochastic integral with respect to harmonizable mBm.We also give Ito formulas and a Tanaka formula with respect to this mBm. In the third chapter we give a new definition, simplier and generalier of multifractiona...